Intensity-modulated radiotherapy (55 Gy in 20 fractions) for high-grade laryngeal dysplasia: report of acute toxicity and functional outcome

The Journal of Laryngology and Otology
J KovarikM S Iqbal

Abstract

Radiotherapy is an option to treat high-grade laryngeal dysplasia. This study aimed to evaluate the use of intensity-modulated radiotherapy, 55 Gy in 20 daily fractions, in treating this disease. Acute toxicity was evaluated in all 14 patients treated. In 10 patients, functional voice outcome was measured using the Voice Handicap Index, and the Grade, Roughness, Breath, Asthenia, Strain ('GRBAS') scale. These measurements were performed pre-treatment and three months after intensity-modulated radiotherapy. All but one patient managed to complete radiotherapy. Acute toxicity was significant (one patient developed grade 4 and three patients developed grade 3 dysphagia). Four patients required hospital admission. In 9 out of 10 patients, radiotherapy improved voice quality. This radiotherapy regimen using intensity-modulated radiotherapy for laryngeal dysplasia is feasible and provided excellent functional outcome, but acute toxicity was significant. Dose de-escalation can be considered in the framework of clinical trials.

References

Jan 1, 1990·International Journal of Radiation Oncology, Biology, Physics·P M MacLeod, F Daniel
Mar 1, 1997·Journal of Voice : Official Journal of the Voice Foundation·M S De BodtC Croux
Nov 14, 2000·Archives of Otolaryngology--head & Neck Surgery·Q T LeK K Fu
Apr 5, 2002·Head & Neck·Allie Garcia-SerraWilliam M Mendenhall
Oct 12, 2004·The Laryngoscope·Clark A RosenThomas Murry
Jul 11, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Maziar SadriAndrew Parker
Aug 19, 2009·Archives of Otolaryngology--head & Neck Surgery·Nestor R RigualBarbara Henderson
Jul 20, 2010·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·H MehannaT Helliwell
Nov 27, 2010·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·M D WellerH M Mehanna
Aug 6, 2011·Journal of Voice : Official Journal of the Voice Foundation·Rachel E ArffaClark A Rosen
Oct 12, 2014·International Journal of Radiation Oncology, Biology, Physics·Leena-Maija AaltonenHeikki Joensuu
Feb 6, 2015·JAMA Otolaryngology-- Head & Neck Surgery·Selmin Karatayli-OzgursoyLee M Akst
Apr 4, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matthew T GreulichStephanie Misono
Apr 5, 2017·World Journal of Otorhinolaryngology - Head and Neck Surgery·Christina MimikosHassan Arshad

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