Intensity-modulated radiotherapy and volumetric-modulated arc therapy have distinct clinical advantages in non-small cell lung cancer treatment

Medical Oncology
Jun ZhangFei Zhao

Abstract

This study was conducted to compare the efficacy of intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) in delivering the planned dosage in the treatment of non-small cell lung cancer (NSCLC). Between September 2013 and March 2014, 125 NSCLC patients were randomly chosen and allocated to the IMRT group (n = 65) and VMAT group (n = 60). We compared multiple parameters such as target dose, organ dosimetry, monitor unit (MU) and time of therapy between IMRT and VMAT groups. The prescribed dose coverage of both planning techniques was 95 % of the planning target volumes (PTVs). PTV 95 % and homogeneous index in IMRT plan were greater than those in VMAT plan (both P < 0.05), while no significant difference in conformity index was observed (P > 0.05). The mean total lung V5 and V10 in VMAT group were markedly higher than those in IMRT group, but the V20, V30, and V40 in VMAT group were significantly lower (all P < 0.05), but no statistically significant difference was observed in V15 and V20 (P > 0.05). Furthermore, the planning spine and esophagus at risk volume showed no statistical significances in both groups (P > 0.05). MU of IMRT plan was about 4.2 % less than that of VMAT plan, which was statist...Continue Reading

References

Sep 22, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Dirk WolffFrank Lohr
Oct 19, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Alex Chang
Feb 9, 2011·International Journal of Radiation Oncology, Biology, Physics·Andrea HoltEugène M F Damen
Sep 13, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Oscar S H ChanAnne W M Lee
Jan 13, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Szu-Huai LuChun-Wei Wang
Jul 13, 2012·Radiation Oncology·Marius TreutweinBarbara Dobler
Jan 16, 2013·Journal of Applied Clinical Medical Physics·Caitlin E MerrowMatthew B Podgorsak
Oct 8, 2013·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·John Agapito
Jan 22, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yasser Abo-MadyanGerhard Glatting
Aug 7, 2014·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Eleonoor A R TheunissenWouter A Dreschler

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Citations

Aug 5, 2016·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Pierre TruntzerGeorges Noël
Dec 10, 2020·British Journal of Cancer·John Conibear, UNKNOWN AstraZeneca UK Limited

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