Intensity of platelet beta(3) integrin in patients with hemorrhagic fever with renal syndrome and its correlation with disease severity

Viral Immunology
Zhengwen LiuNi Zhang

Abstract

beta(3) Integrin has been identified as a cellular receptor for Hantaan virus, which causes hemorrhagic fever with renal syndrome (HFRS). To investigate the relationship between intensity of the platelet membrane beta(3) integrin (CD61) and disease severity, the percentage of CD61-positive platelets and the mean fluorescence intensities (MFI) of platelet CD61 were determined in patients with HFRS by flow cytometry. The intensity levels of CD61 in patients with HFRS were significantly higher than those in the controls and correlated with the clinical phases of the disease. The CD61 intensity at the oliguric phase was inversely correlated with platelet count and serum albumin, and positively correlated with white blood cell count, blood urea nitrogen, serum creatinine, and alanine aminotransferase levels. The results suggest that the intensity levels of platelet CD61 were elevated and associated with clinical phases and disease severity in patients with HFRS, and the intensity of platelet beta(3) integrin in patients with HFRS may be indicative of disease severity.

References

Mar 1, 1978·The Journal of Infectious Diseases·H W LeeK M Johnson
Feb 1, 1994·Virus Research·M LiangC S Schmaljohn
Apr 1, 1997·Emerging Infectious Diseases·C Schmaljohn, B Hjelle
Jan 23, 1999·The Journal of Clinical Investigation·K M Hodivala-DilkeR O Hynes
Feb 24, 2001·Current Topics in Microbiology and Immunology·E R Mackow, I N Gavrilovskaya
Jan 12, 2002·Nature Medicine·Louise E ReynoldsKairbaan M Hodivala-Dilke
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Erika GeimonenErich R Mackow
Oct 12, 2002·Archives of Virology·I N GavrilovskayaE R Mackow
Jan 7, 2003·Viral Immunology·Svetlana F Khaiboullina, Stephen C St Jeor
Jul 8, 2003·The Journal of Pathology·Bernhard Wehrle-Haller, Beat A Imhof
Aug 7, 2003·Journal of Vascular Research·Luis A Martinez-LemusGerald A Meininger
Aug 19, 2003·Journal of Korean Medical Science·Hyeong Su KimKun Sei Lee
Aug 30, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·G A Stouffer, S S Smyth
Oct 14, 2003·Journal of Korean Medical Science·Young Ok KimByung Kee Bang
May 12, 2005·Experimental & Molecular Medicine·Jin-Won SongKwangSook Park
Oct 1, 2005·The Journal of Physiology·Mack H Wu
Nov 29, 2005·Biochemical and Biophysical Research Communications·Dan Lei MouXue Fan Bai

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Citations

Aug 30, 2012·Journal of Medical Virology·M GoeijenbierE C M van Gorp
Aug 21, 2008·Journal of Medical Virology·Zhengwen LiuNi Zhang
Apr 13, 2019·Viruses·Soerajja BhoelanMarco Goeijenbier

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