PMID: 70098May 1, 1977Paper

Intensity renewal of skin and serum soluble proteins in rats with vitamin A deficiency

Ukrainskiĭ biokhimicheskiĭ zhurnal
E M Liubavich, P L Naumchuk

Abstract

Intensity of skin and blood serum soluble proteins renewal under conditions of vitamin A deficiency in animal organism was studied with application of the label incorporation into the electrophoretic fractions of proteins 1,3 and 24 h after administration of 14C-lysine. Metabolism of collagen proteins, amino acid composition of skin soluble proteins, content of free amino acids and nucleic acid in skin were also examined. With vitamin A deficiency the intensity of 14C-lysine incorporation into the globulin fractions of serum proteins is 2-4 times as high and into the corresponding fractions of skin proteins is 3-5 times as low as in the control. Metabolism of gamma-globulins and collagen proteins of skin under conditions of vitamin A deficiency is found to be slow. The content of DNA and RNA in skin of the avitaminous animals is reliably 17 and 23% lower, respectively. In the skin extracts obtained by means of 0.15 M NaCl the content of free amino acids with vitamin A deficiency increases. No significant changes are found in the amino acid composition of skin proteins soluble in 0.15 M NaCl, with the exception for a 20% decrease in the content of cystine together with cystein.

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