Intensity response function of the photopic negative response (PhNR): effect of age and test-retest reliability

Documenta Ophthalmologica. Advances in Ophthalmology
Nabin R JoshiSuresh Viswanathan

Abstract

To assess the effect of age and test-retest reliability of the intensity response function of the full-field photopic negative response (PhNR) in normal healthy human subjects. Full-field electroretinograms (ERGs) were recorded from one eye of 45 subjects, and 39 of these subjects were tested on two separate days with a Diagnosys Espion System (Lowell, MA, USA). The visual stimuli consisted of brief (<5 ms) red flashes ranging from 0.00625 to 6.4 phot cd.s/m2, delivered on a constant 7 cd/m2 blue background. PhNR amplitudes were measured at its trough from baseline (BT) and from the preceding b-wave peak (PT), and b-wave amplitude was measured at its peak from the preceding a-wave trough or baseline if the a-wave was not present. The intensity response data of all three ERG measures were fitted with a generalized Naka-Rushton function to derive the saturated amplitude (V max), semisaturation constant (K) and slope (n) parameters. Effect of age on the fit parameters was assessed with linear regression, and test-retest reliability was assessed with the Wilcoxon signed-rank test and Bland-Altman analysis. Holm's correction was applied to account for multiple comparisons. V max of BT was significantly smaller than that of PT and b-...Continue Reading

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Citations

Jun 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·Nefeli SlaviMiduturu Srinivas
Jan 5, 2020·Japanese Journal of Ophthalmology·Yuji HaraTomoharu Nishimura
Jun 2, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Laura FrishmanSuresh Viswanathan
Apr 15, 2020·Journal of Glaucoma·Yoshiyuki KitaAkito Hirakata
Aug 2, 2020·International Ophthalmology·Matteo PrencipeMario Perossini
Jan 9, 2019·Translational Vision Science & Technology·Flora HuiJonathan G Crowston
Jul 19, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Adriana BerezovskySolange Rios Salomão
Jan 9, 2019·Translational Vision Science & Technology·Jessica TangJonathan G Crowston
Sep 13, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Atsuhiro TanikawaMasayuki Horiguchi
Jun 13, 2021·Eye·Oliver R Marmoy, Suresh Viswanathan
Oct 17, 2019·Schizophrenia Research·Pantea MoghimiRobert F Miller

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