Intensive care acquired infection is an independent risk factor for hospital mortality: a prospective cohort study.

Critical Care : the Official Journal of the Critical Care Forum
Pekka YlipalosaariHannu Syrjälä

Abstract

The aim of this study was to elucidate the impact of intensive care unit (ICU)-acquired infection on hospital mortality. Patients with a longer than 48 hour stay in a mixed 10 bed ICU in a tertiary-level teaching hospital were prospectively enrolled between May 2002 and June 2003. Risk factors for hospital mortality were analyzed with a logistic regression model. Of 335 patients, 80 developed ICU-acquired infection. Among the patients with ICU-acquired infections, hospital mortality was always higher, regardless of whether or not the patients had had infection on admission (infection on admission group (IAG), 35.6% versus 17%, p = 0.008; and no-IAG, 25.7% versus 6.1%, p = 0.023). In IAG (n = 251), hospital stay was also longer in the presence of ICU-acquired infection (median 31 versus 16 days, p < 0.001), whereas in no-IAG (n = 84), hospital stay was almost identical with and without the presence of ICU-acquired infection (18 versus 17 days). In univariate analysis, the significant risk factors for hospital mortality were: Acute Physiology and Chronic Health Evaluation (APACHE) II score >20, sequential organ failure assessment (SOFA) score >8, ICU-acquired infection, age > or = 65, community-acquired pneumonia, malignancy or i...Continue Reading

References

Oct 1, 1992·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·T C HoranT G Emori
Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
May 1, 1988·Archives of Internal Medicine·D E CravenW R McCabe
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·E GirouJ Y Fagon
Jul 8, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L SoufirS Chevret
Jun 2, 2000·Critical Care Medicine·S P Ponce de León-RosalesV G Vázquez-Ramos
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·J RelloJ Valles
May 31, 2001·Anesthesiology·F BregeonL Papazian
Jun 26, 2001·Acta Anaesthesiologica Scandinavica·P AppelgrenU Ransjö
Dec 18, 2001·Chest·P Eggimann, D Pittet
Mar 22, 2002·Intensive Care Medicine·Corinne AlbertiRoger Le Gall
Mar 22, 2002·Intensive Care Medicine·Pierre MoineUNKNOWN OUTCOMEREA study group
Dec 10, 2002·Archives of Surgery·Stephan HarbarthDidier Pittet
Dec 12, 2002·Chest·Jordi RelloUNKNOWN VAP Outcomes Scientific Advisory Group
Sep 13, 2003·Acta Anaesthesiologica Scandinavica·S VosyliusJ Ivaskevicius
Jan 7, 2004·World Journal of Surgery·Robert R HutchinsNeil C Soni
Nov 5, 2004·Intensive Care Medicine·Elie AzoulayUNKNOWN European Sepsis Group
Oct 11, 2005·Critical Care Medicine·Nasia SafdarSanjay Saint
Oct 29, 2005·Journal of Critical Care·Eva TejerinaUNKNOWN International Mechanical Ventilation Study Group
Feb 8, 2006·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Wendy SliglPeter G Brindley

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Citations

Sep 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Sarah E SiegelaarJ Hans DeVries
Mar 10, 2007·Critical Care : the Official Journal of the Critical Care Forum·Pekka YlipalosaariHannu Syrjälä
Mar 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Burcin OzerSelim Turhanoglu
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Oznur AkSerhan Çolakoğlu
Oct 14, 2014·Journal of Tropical Medicine·Keshni NaiduKaren Bissell
Dec 22, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·P Cornejo-JuárezP Volkow-Fernández
Jun 12, 2013·Journal of Intensive Care Medicine·Sumanth Gandra, Richard T Ellison
Dec 6, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Samantha HoneywellDiane Rigassio Radler
Jul 13, 2020·The Journal of Antimicrobial Chemotherapy·Yii-Lih LinFredrik Westerlund
Dec 3, 2016·Critical Care : the Official Journal of the Critical Care Forum·Si YangLijun Ma
Jul 25, 2019·Journal of Clinical Medicine·Chun-Ta HuangChong-Jen Yu
Apr 23, 2020·Expert Review of Clinical Pharmacology·Dario CattaneoDeborah Je Marriott
Jan 27, 2021·Health Care Management Science·Eduardo Pérez, David P Dzubay
Apr 2, 2021·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Chintamani AbhishekRamesh Venkataraman

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