Intensive follow-up strategies after radical surgery for nonmetastatic colorectal cancer: A systematic review and meta-analysis of randomized controlled trials

PloS One
Yaqin ZhaoAndrew Faramand

Abstract

Intensive follow-up after surgery for colorectal cancers is common in clinical practice, but evidence of a survival benefit is limited. To conduct a systematic review and meta-analysis on the effects of follow-up strategies for nonmetastatic colorectal cancer. We searched Medline, Embase, and CENTRAL databases through May 30, 2018. We included randomized clinical trials evaluating intensive follow-up versus less follow-up in patients with nonmetastatic colorectal cancer. Intensive follow-up. Overall survival. The analyses included 17 trials with a total of 8039 patients. Compared with less follow-up, intensive follow-up significantly improved overall survival in patients with nonmetastatic colorectal cancer after radical surgery (HR 0.85, 95% CI 0.74-0.97, P = 0.01; I2 = 30%; high quality). Subgroup analyses showed that differences between intensive-frequency and intensive-test follow-up (P = 0.04) and between short interval and long interval of follow-up (P = 0.02) in favor of the former one. Clinical heterogeneity of interventions. For patients with nonmetastatic colorectal cancer after curative resection, intensive follow-up strategy was associated with an improvement in overall survival compared with less follow-up strategy...Continue Reading

References

Nov 18, 1995·BMJ : British Medical Journal·A WaghornM McKee
Jun 1, 1995·Diseases of the Colon and Rectum·B OhlssonK G Tranberg
Jun 21, 1995·JAMA : the Journal of the American Medical Association·K S VirgoF E Johnson
May 1, 1997·The British Journal of Surgery·B J KjeldsenO D Jørgensen
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jun 8, 2002·World Journal of Surgery·Matthias W WichmannFriedrich-Wilhelm Schildberg
Jul 9, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Giovanni B SeccoRomano Ferraris
Jul 19, 2003·Seminars in Oncology·Jeffrey A Meyerhardt, Robert J Mayer
Dec 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francisco Rodríguez-MorantaAntoni Castells
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
May 19, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E StrandK Smedh
Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K SøreideH Kørner
Dec 12, 2012·Diseases of the Colon and Rectum·Dorin T ColibaseanuEric J Dozois
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R LabiancaUNKNOWN ESMO Guidelines Working Group
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B GlimeliusUNKNOWN ESMO Guidelines Working Group
Nov 14, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey A MeyerhardtUNKNOWN American Society of Clinical Oncology
Dec 12, 2013·European Journal of Clinical Nutrition·S CohenR Lubetzky
Dec 24, 2014·International Journal of Nursing Practice·Craig Lockwood, Cindy Stern
Jul 18, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C J VerberneT Wiggers
Nov 19, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G RosatiUNKNOWN GILDA working group
Aug 5, 2016·The British Journal of Surgery·S MokhlesT Treasure
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
May 26, 2018·JAMA : the Journal of the American Medical Association·Hanna K Sanoff
May 26, 2018·JAMA : the Journal of the American Medical Association·Rebecca A SnyderUNKNOWN Alliance for Clinical Trials in Oncology Network Cancer Surveillance Optimization Working Group

❮ Previous
Next ❯

Citations

Jan 16, 2021·International Journal of Colorectal Disease·Felix WiesmuellerChristian Krautz
Feb 18, 2021·Journal of Surgical Oncology·Rayyan S MirdadTimothy M Pawlik
Apr 15, 2021·Journal of Cancer Survivorship : Research and Practice·Ulrike BoehmerAl Ozonoff
Nov 7, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Jacques MonteilNicole Tubiana-Mathieu

❮ Previous
Next ❯

Methods Mentioned

BETA
FACS

Software Mentioned

RevMan
PROSPERO

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.