PMID: 11328379May 1, 2001Paper

Intensive generation of NK1.1- extrathymic T cells in the liver by injection of bone marrow cells isolated from mice with a mutation of polymorphic major histocompatibility complex antigens

Immunology
R C HalderT Abo

Abstract

Whether intermediate TCR (TCRint) cells and natural killer T (NKT or NK1.1+TCRint) cells are extrathymically generated remains controversial. This arises from the fact that there are few of these T cells in athymic nude mice and neonatally thymectomized mice. However, when athymic mice were provided with appropriate microenvironments or stimulation, many TCRint cells (mainly NK1.1-) were found to arise in the liver. NKT cells are known to be positively selected by monomorphic major histocompatibility complex (MHC) -like antigens (e.g. CD1d). This is true even if they are CD4+. In other words, a MHC class I-like antigen is restricted to CD4 antigen. This rule is somewhat different from that seen in conventional T cells (i.e. the restriction of class II with CD4 and that of class I and CD8). In the case of NK1.1-TCRint cells, they were selected by polymorphic MHC antigens, but their MHC restriction to CD4 or CD8 antigen was incomplete. This was revealed by experiments of bone marrow transfer with class I (bm 1) or II (bm 12) disparity. Depending on the disparity, a unique cytokine profile in sera was detected. These results suggest that the development of T lineage lymphocytes and MHC restriction to CD4 and CD8 might have occurre...Continue Reading

References

Oct 1, 1991·Immunological Reviews·A Bendelac, R H Schwartz
Nov 1, 1990·The Journal of Experimental Medicine·L A JonesA M Kruisbeck
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M PearseK Shortman
Aug 1, 1987·The Journal of Experimental Medicine·R C BuddH R MacDonald
Jul 1, 1985·Immunological Reviews·R A FlavellG Widera
May 12, 1995·Science·A BendelacR R Brutkiewicz
Apr 1, 1994·The Journal of Experimental Medicine·T Yoshimoto, W E Paul
May 1, 1993·The Journal of Experimental Medicine·Y MakinoM Taniguchi
Jan 1, 1997·Annual Review of Immunology·A BendelacJ H Roark
Oct 31, 1998·International Immunology·K HammondD Godfrey
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·S TangriM Kronenberg
Oct 30, 1999·European Journal of Immunology·F TilloyO Lantz

❮ Previous
Next ❯

Citations

Dec 11, 2003·Parasitology International·Ramesh C HalderToru Abo
May 3, 2011·American Journal of Respiratory and Critical Care Medicine·Angela Panoskaltsis-MortariUNKNOWN American Thoracic Society Committee on Idiopathic Pneumonia Syndrome
Aug 4, 2006·The Journal of Parasitology·Anoja AriyasingheToru Abo
Apr 6, 2012·Immunologic Research·Toru AboHisami Watanabe
Jun 23, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Noam RudichOri Wald
Sep 12, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B SisP F Halloran
Feb 21, 2007·Scandinavian Journal of Immunology·M A Rodríguez-MonroyLeticia Moreno-Fierros
Jul 27, 2002·Cellular Immunology·Sen WangToru Abo
Jul 1, 2008·Gastroenterology·Diarmaid Dominic Houlihan, Philip Noel Newsome
Jul 4, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Liu YangAnna Mae Diehl
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Kaiissar MannoorToru Abo
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Megan S FordLi Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.