Intensive intracorneal keloid formation in a case of Peters plus syndrome and in Peters anomaly with maximum manifestation

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
P EberweinC Auw-Haedrich


We present two cases of Peters anomaly (Peters plus syndrome and a maximum manifestation variant) with abnormally thickened cornea and corneal staphyloma. Both patients presented to our hospital shortly after birth and were treated with perforating keratoplasty and lensectomy. Histological analysis showed marked thickening of the corneal stroma due to abnormal stromal connective tissue deposition. Additionally, both eyes showed the characteristic changes of Peters anomaly with corneal opacity, adherence of the iris stroma and anterior lens surface to the posterior corneal surface, absence of the corneal endothelium, Descemet and Bowmans layers. Peters anomaly with abnormally thick intracorneal fibrosis with or without congenital corneal staphyloma is a very rare manifestation.


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Nov 14, 2001·Ophthalmology Clinics of North America·L L Yang, S R Lambert
Mar 28, 2003·Ophthalmic Genetics·Marijean M MillerManuel Pontigo
Feb 18, 2006·Klinische Monatsblätter für Augenheilkunde·J M RohrbachK Siepmann
Aug 16, 2006·American Journal of Human Genetics·Saskia A J Lesnik ObersteinRaoul C M Hennekam
Jul 25, 2008·Cornea·Kavita V RaoVirender S Sangwan
Oct 2, 2008·The Ocular Surface·M VanathiSeema Sen

Related Concepts

Multiple Congenital Anomalies
Corneal Diseases
Eye Abnormalities
Lens, Crystalline
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