Intensive lifestyle treatment for non-alcoholic fatty liver disease in children with severe obesity: inpatient versus ambulatory treatment

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Bart G P KootMarc A Benninga

Abstract

Lifestyle intervention is the only established therapy for non-alcoholic fatty liver disease (NAFLD). The optimal treatment schedule and predictors of response of this treatment have not been established in children. We aimed to evaluate the 2-year efficacy of an inpatient versus ambulatory intensive lifestyle intervention for treating NAFLD in children with severe obesity. A cohort study of 51 severely obese non-diabetic children (mean age 14.7 (±2.4) years; BMI-z-score 3.5 (±0.5)) with liver steatosis were non-randomly allocated to inpatient treatment (2 or 6 months), ambulatory treatment or usual care. Proton Magnetic Resonance Spectroscopy determined liver steatosis and serum alanine aminotransferase (ALT) at 6 months were the primary outcome measures. Baseline variables were evaluated as predictors of treatment response. Liver steatosis had disappeared in 43, 29 and 22% and serum ALT normalized in 41, 33 and 6% at the end of 6 months in the inpatient, ambulatory or usual care treatment groups, respectively. Only the proportions of ALT normalization in inpatient and ambulatory treatment compared with usual care were significantly higher. Treatment effects of inpatient and ambulatory treatment were sustained at 1.5 years fol...Continue Reading

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Citations

Apr 5, 2016·Digestive Diseases and Sciences·Jonathan A AfricaJeffrey B Schwimmer
Aug 28, 2016·Eating and Weight Disorders : EWD·Antonella MoscaValerio Nobili
Jul 18, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga ChalasaniArun J Sanyal
Aug 3, 2020·Journal of Pediatric Gastroenterology and Nutrition·Laura G DraijerBart G P Koot
Mar 23, 2017·Childhood Obesity·Katherine González-RuizAntonio García-Hermoso
Sep 19, 2020·Journal of Pediatric Gastroenterology and Nutrition·Laura G DraijerBart G P Koot
Jun 29, 2021·Current Pharmaceutical Design·Tanya RalliKanchan Kohli

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