May 18, 2020

Intensive therapy with gastropodan hemocyanins increases their antitumor properties in murine model of colon carcinoma

International Immunopharmacology
Emiliya StoyanovaAndrey Tchorbanov

Abstract

Various natural compounds have been tested as anticancer therapeutics in clinical trials. Most promising direction for antitumor therapy is the use of substances which enhance the immune system response stimulating tumor-specific lymphocytes. Hemocyanins are large extracellular oxygen transport glycoproteins isolated from different arthropod and mollusk species which exhibit strong anticancer properties. Immunized in mammals they trigger Th1 immune response that promotes unspecific stimulation and adjuvant activity in experimental therapeutic vaccines for cancer and antibody development. In the present study we used two hemocyanins - one isolated from marine snail Rapana thomasiana (RtH) and another one, from the terrestrial snail Helix pomatia (HpH) which have been investigated by using different administration schedules (intensive and mild) in murine model of colon carcinoma. The treatment with RtH and HpH generated high levels of antitumor IgG antibodies, antibody-producing plasma cells and tumor-specific CTLs, stimulated secretion of proinflammatory cytokines, suppressed the manifestation of carcinoma symptoms as tumor growth and size, and prolonged the life span of treated mice. Our results showed a significant anti-cancer...Continue Reading

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Mentioned in this Paper

Cytokine
Helix pomatia
Administration Procedure
Colon Carcinoma
Laboratory mice
Immune Response
Antineoplastic Agents
Plasma Cells
Size
Cross Reactions

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