PMID: 2509264Oct 1, 1989Paper

Intention to treat febrile convulsions with rectal diazepam, valproate or phenobarbitone

Developmental Medicine and Child Neurology
I McKinlay, R W Newton

Abstract

One hundred and eighty-six consecutive children aged between six and 72 months admitted to the Manchester Children's Hospitals with a febrile convulsion in the first year of life, a complicated febrile convulsion, or more than one febrile convulsion within two years, were allocated randomly to one of three groups who were offered rectal diazepam in the event of a subsequent prolonged febrile convulsion, or prophylactic treatment with sodium valproate or phenobarbitone. Over-all risk of recurrence was 30 per cent and adequate prophylactic treatment did not lessen this risk. Side-effects in 24 per cent of the valproate group and 61 per cent of the phenobarbitone group did not justify the use of prophylactic treatment.

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Citations

Jun 18, 1998·Arquivos de neuro-psiquiatria·M L ManrezaA Diament
Feb 23, 2017·The Cochrane Database of Systematic Reviews·Martin OffringaSarah J Nevitt
Aug 1, 1991·Postgraduate Medicine·R F MonsenG F Snell
Dec 20, 2005·Acta Neurologica Scandinavica. Supplementum·P Wolf
Nov 30, 1991·BMJ : British Medical Journal·R J Robinson
Jul 1, 1995·Journal of Child Neurology·Y A al-Eissa
Jan 1, 1995·Epilepsia·B F Bourgeois
Jul 24, 2013·Evidence-based Child Health : a Cochrane Review Journal·Martin Offringa, Richard Newton
Aug 16, 1990·The New England Journal of Medicine
Feb 6, 2004·Arquivos de neuro-psiquiatria·Alice Hatsue MasukoGilmar Fernandes do Prado
Jun 17, 2021·The Cochrane Database of Systematic Reviews·Martin OffringaKaterina Vraka

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