Intentional Weight Loss and Longevity in Overweight Patients with Type 2 Diabetes: A Population-Based Cohort Study

PloS One
Rasmus Køster-RasmussenNiels de Fine Olivarius

Abstract

This study examined the influence of weight loss on long-term morbidity and mortality in overweight (BMI≥25 kg/m2) patients with type 2 diabetes, and tested the hypothesis that therapeutic intentional weight loss supervised by a medical doctor prolongs life and reduces the risk for cardiovascular disease in these patients. This is a 19 year cohort study of patients in the intervention arm of the randomized clinical trial Diabetes Care in General Practice. Weight and prospective intentions for weight loss were monitored every third month for six years in 761 consecutive patients (≥40 years) newly diagnosed with diabetes in general practices throughout Denmark in 1989-92. Multivariable Cox regression was used to estimate the association between weight change during the monitoring period (year 0 to 6) and the outcomes during the succeeding 13 years (year 6 to 19) in 444 patients who were overweight at diagnosis and alive at the end of the monitoring period (year 6). The analysis was adjusted for age, sex, education, BMI at diagnosis, change in smoking, change in physical activity, change in medication, and the Charlson comorbidity 6-year score. Outcomes were from national registers. Overall, weight loss regardless of intention was...Continue Reading

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Citations

Mar 24, 2018·Obesity·Katherine M Flegal, John P A Ioannidis
Nov 16, 2018·Current Medical Research and Opinion·Kuat OshakbayevBibazhar Dukenbayeva
May 5, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Duk-Hee LeeP Monica Lind
Jul 27, 2018·Gerontology & Geriatric Medicine·Mikael RennemarkJohan Sanmartin-Berglund
Jan 17, 2021·American Journal of Hypertension·Jeonggyu KangKi-Chul Sung
Dec 15, 2018·Medicine and Science in Sports and Exercise·Glenn A Gaesser, Steven N Blair

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