Inter and intra ethnic variation of vitamin K epoxide reductase complex and cytochrome P450 4F2 genetic polymorphisms and their prevalence in South Indian population

Indian Journal of Human Genetics
Dhakchinamoorthi Krishna KumarChandrasekaran Adithan

Abstract

Genetic variation in the vitamin K epoxide reductase complex (VKORC1) and cytochrome P450 4F2 (CYP4F2) genes were found to be strongly associated with the oral anticoagulant (OA) dose requirement. The distribution of genetic variation in these two genes was found to show large inter- and intra-ethnic difference. A total of 470 unrelated, healthy volunteers of South Indians of either sex (age: 18-60 years) were enrolled for the study. A 5 ml of venous blood was collected and the genomic deoxyribonucleic acid (DNA) was extracted by using phenol-chloroform extraction method. Real-time quantitative polymerase chain reaction (RT-PCR) method was used for genotyping. The variant allele frequencies of VKORC1 rs2359612 (T), rs8050894 (C), rs9934438 (T) and rs9923231 (A) were found to be 11.0%, 11.8%, 11.7% and 12.0%, respectively. The variant allele VKORC1 rs7294 was (80.1%) more frequent and the variant allele CYP4F2 * 3 was found to be 41.8% in South Indians. The allele, genotype and haplotype frequencies of VKORC1 and CYP4F2 gene were distinct from other compared HapMap populations (P < 0.0001). The findings of our study provide the basic genetic information for further pharmacogenetic based investigation of OA therapy in the populat...Continue Reading

References

Nov 1, 1994·Annals of Internal Medicine·P S WellsJ Hirsh
Oct 1, 1996·Pharmacogenetics·M J StubbinsC R Wolf
Apr 3, 2002·JAMA : the Journal of the American Medical Association·Mitchell K HigashiAllan E Rettie
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jan 20, 2005·European Journal of Human Genetics : EJHG·Sarah L SawyerKenneth K Kidd
Jan 22, 2005·Fundamental & Clinical Pharmacology·Rosemary JoseKrishnamoorthy Rajagopal
Jun 3, 2005·The New England Journal of Medicine·Mark J RiederAllan E Rettie
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Aug 2, 2006·Biological & Pharmaceutical Bulletin·Amrithraj Theophilus NaveenRajagopal Krishnamoorthy
Oct 19, 2006·Human Genetics·Mia WadeliusPanos Deloukas
Oct 2, 2007·Journal of Thrombosis and Thrombolysis·Brian F Gage, Lawrence J Lesko
Nov 9, 2007·Circulation·Jeffrey L AndersonUNKNOWN Couma-Gen Investigators
Nov 13, 2007·British Journal of Clinical Pharmacology·Suman LalBalram Chowbay
Feb 6, 2008·Blood·Michael D CaldwellJames K Burmester
Aug 12, 2008·Current Clinical Pharmacology·Todd E DumasCraig R Lee
Aug 14, 2008·Clinical Pharmacokinetics·Simone StehleUwe Fuhr
Aug 30, 2008·Clinical Pharmacology and Therapeutics·J A PeriniG Suarez-Kurtz
Feb 21, 2009·The New England Journal of Medicine·UNKNOWN International Warfarin Pharmacogenetics ConsortiumJ A Johnson
Sep 26, 2009·Nature·David ReichLalji Singh
May 28, 2010·Pharmacogenomics·Stuart A ScottRobert J Desnick
Nov 19, 2010·Drug Metabolism and Pharmacokinetics·Onkar SinghBalram Chowbay
Jan 27, 2011·Fundamental & Clinical Pharmacology·D KrishnakumarC Adithan
Mar 2, 2011·The Pharmacogenomics Journal·A PavaniV K Kutala
Mar 8, 2011·Genetic Testing and Molecular Biomarkers·Annan Sudarsan Arun KumarChandrasekaran Adithan

❮ Previous
Next ❯

Citations

Dec 18, 2013·Indian Journal of Human Genetics·Tejasvita GaikwadKanjaksha Ghosh
Jan 1, 2019·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Devendra SaksenaUNKNOWN VHD India consensus committee

❮ Previous
Next ❯

Datasets Mentioned

BETA
AY587020

Methods Mentioned

BETA
genotyping

Software Mentioned

HAPLOVIEW
GraphPad InStat
GraphPad
7300 SDS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Elisabete JorgeLuís A Providência
Journal of Pharmacology & Pharmacotherapeutics
Dhakchinamoorthi Krishna KumarChandrasekaran Adithan
© 2021 Meta ULC. All rights reserved