INTER-HEART: A global study of risk factors for acute myocardial infarction

American Heart Journal
S OunpuuS Yusuf

Abstract

Although declines in mortality rates have occurred in most developed countries, increases are being seen in developing countries. Our knowledge of risk factors for acute myocardial infarction (AMI) is largely derived from studies in the former. Applicability of these results to other populations is unknown. The objectives of INTER-HEART are to determine the association between risk factors and AMI within populations defined by ethnicity and/or geographic region and to assess the relative importance of risk factors across these populations. INTER-HEART is a study of 14,000 cases of AMI and 16,000 matched control patients from 46 countries, which was conducted with a standardized protocol. Questionnaires were translated into 11 languages; physical measurements were obtained, and 20 mL of blood was drawn and shipped frozen to a central laboratory in Canada. The study will evaluate the importance of conventional and emerging risk factors within each geographic region and whether their impact varies by region. INTER-HEART is sponsored by the World Health Organization and the World Heart Federation and has received funding from several peer-reviewed agencies and many different pharmaceutical companies. A vanguard phase (February 1999...Continue Reading

Citations

Jan 6, 2010·International Journal of Environmental Research and Public Health·Selma MetintasInci Arikan
Mar 8, 2019·European Heart Journal. Quality of Care & Clinical Outcomes·Zaid I AlmarzooqMonika M Safford
Mar 15, 2005·International Journal of Epidemiology·Anwar T MerchantSalim Yusuf
Jan 13, 2006·BMC Cardiovascular Disorders·Carlos E D'NegriDaniel P Cardinali
Mar 7, 2007·Circulation·Fernando LanasUNKNOWN INTERHEART Investigators in Latin America
Feb 19, 2009·Clinical Pharmacology and Therapeutics·S P Kishore, B J Herbstman
Mar 13, 2008·European Heart Journal·Sonia S AnandUNKNOWN INTERHEART Investigators
Jul 13, 2012·American Journal of Hypertension·Sergio L RodriguesRoberto de Sa Cunha
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May 1, 2021·Journal of Community Health·Amanda WeinmannRussell Luepker
Jan 17, 2009·Journal of the American College of Cardiology·Ganesan KarthikeyanSalim Yusuf

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