Inter-hemispheric wave propagation failures in traumatic brain injury are indicative of callosal damage

Vision Research
Daniel P SpiegelReza Farivar

Abstract

Approximately 3.2-5.3 million Americans live with the consequences of a traumatic brain injury (TBI), making TBI one of the most common causes of disability in the world. Visual deficits often accompany TBI but physiological and anatomical evidence for injury in mild TBI is lacking. Axons traversing the corpus callosum are particularly vulnerable to TBI. Hemifield representations of early visual areas are linked by bundles of fibers that together cross the corpus callosum while maintaining their topographic relations. Given the increased vulnerability of the long visual axons traversing the corpus callosum, we hypothesized that inter-hemispheric transmission for vision will be impaired following mild TBI. Using the travelling wave paradigm (Wilson, Blake, & Lee 2001), we measured inter-hemispheric transmission in terms of both speed and propagation failures in 14 mild TBI patients and 14 age-matched controls. We found that relative to intra-hemispheric waves, inter-hemispheric waves were faster and that the inter-hemispheric propagation failures were more common in TBI patients. Furthermore, the transmission failures were topographically distributed, with a bias towards greater failures for transmission across the upper visual ...Continue Reading

References

Jan 1, 1989·The International Journal of Biochemistry·T GauthierJ C Murat
Oct 20, 1994·Behavioural Brain Research·M Brysbaert
Sep 1, 1993·Brain Injury : [BI]·K SchlageterR Sammet
Jan 1, 1993·Neurology·S IshiaiS Watabiki
Aug 1, 1996·Italian Journal of Neurological Sciences·A R GiovagnoliE Capitani
Jan 1, 1997·Spatial Vision·D H Brainard
Aug 10, 1999·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·D A BenavidezH S Levin
Apr 20, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·A V ChistyakovM Feinsod
Aug 31, 2001·Nature·H R WilsonS H Lee
Apr 16, 2002·Seminars in Speech and Language·Julie A G Stierwalt, Laura L Murray
May 31, 2002·Current Treatment Options in Neurology·Neera Kapoor, Kenneth J. Ciuffreda
Sep 24, 2005·Journal of Neurosurgery·Matilde IngleseRobert I Grossman
Sep 1, 2007·Neurosurgery·Louis De BeaumontHugo Théoret
Dec 25, 2007·Optometry : Journal of the American Optometric Association·Kenneth J CiuffredaM E Han
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Steven M MillerMargaret J Wright
Mar 18, 2010·The Journal of Head Trauma Rehabilitation·John D CorriganJean A Langlois Orman
Sep 3, 2011·Current Biology : CB·Erhan GençAxel Kohler
Nov 23, 2011·Acta Neurologica Scandinavica·J TallusO Tenovuo
May 25, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Susanne Schuett, Josef Zihl
Jul 19, 2012·Current Opinion in Ophthalmology·Kammi B Gunton, Aʼsha Brown
Aug 18, 2012·Brain Injury : [BI]·Brian D GreenwaldAdeepa D Singh
Apr 23, 2013·Current Biology : CB·Anouk M van LoonVictor A F Lamme

❮ Previous
Next ❯

Citations

Mar 1, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Richard A Armstrong
Nov 5, 2019·Vision Research·Luminita Tarita-NistorEsther G González

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.