Inter-individual differences in the impulsive/compulsive dimension: deciphering related dopaminergic and serotonergic metabolisms at rest

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Françoise Dellu-HagedornPhilippe De Deurwaerdère

Abstract

Several impulse control disorders such as ADHD, mania, personality disorders or substance abuse share common behavioural traits, like impulsiveness, risk-taking or inflexible behaviour. These disorders are treated with drugs targeting dopamine (DA) and/or serotonin (5-HT). However, the patient's monoamine imbalance that these neurotransmitters compensate is unclear. This study aims to investigate the patterns of DA and 5-HT metabolisms at rest within selected brain regions related to inter-individual variability in six main components of impulsivity/compulsivity (anticipatory hyperactivity, premature responses, delay discounting, risk-taking, perseveration, flexibility). Rats with adaptive and highly inadaptive behaviours were identified in each task and a sensitive biochemical approach allowed mapping of post-mortem endogenous monoamine tissue content in 20 brain areas. Distinct patterns of 5-HT and DA metabolisms were revealed according to the behavioural traits. Except for hyperactive responses, lower control of actions was mainly associated with a lower DA or 5-HT metabolism in prefrontal and/or subcortical areas (i.e. in orbitofrontal cortex (DA), amygdala and anterior cingulate cortex (5-HT) for inflexible and risk-prone ...Continue Reading

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Citations

Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I TrofimovaJ Uher
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T W Robbins
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jana UherLouis A Schmidt
Jul 28, 2020·Frontiers in Pharmacology·Giuseppe Di GiovanniPhilippe De Deurwaerdère
Mar 4, 2020·International Journal of Molecular Sciences·Julien Bacqué-CazenavePhilippe De Deurwaerdère
Aug 14, 2020·International Journal of Molecular Sciences·Rahul BharatiyaPhilippe De Deurwaerdere
Jul 25, 2019·Frontiers in Behavioral Neuroscience·Cristian Perez-FernandezFernando Sánchez-Santed
Jan 28, 2019·Neurochemistry International·Abdeslam ChagraouiPhilippe De Deurwaerdère

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