Abstract
To assess the reproducibility of biexponential R2 -relaxometry MRI for estimation of liver iron concentration (LIC) between proprietary and nonproprietary analysis methods. This single-center retrospective study, approved by investigational review board and compliant with the Health Insurance Portability and Accountability Act, included 40 liver MRI exams in 38 subjects with suspected or known iron overload. From spin-echo images of the liver, acquired at 5 different echo times (TE = 6-18 ms), biexponential R2 maps were calculated using 1 proprietary (FerriScan, Resonance Health Ltd., Claremont WA, Australia) and 3 nonproprietary (simulated annealing, nonlinear least squares, dictionary search) analysis methods. Each subject's average liver R2 value was converted to LIC using a previously validated calibration curve. Inter-method reproducibility for liver R2 and LIC were assessed for linearity using linear regression analysis and absolute agreement using intraclass correlation and Bland-Altman analysis. For point estimates, 95% confidence intervals were calculated; P values < 0.05 were considered statistically significant. Linearity between the proprietary and nonproprietary methods was excellent across the observed range for R...Continue Reading
References
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M L BassettL W Powell
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·G D McLarenR W Kellermeyer
Dec 29, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·H G KreeftenbergC H Gips
Sep 1, 1994·The New England Journal of Medicine·G M BrittenhamJ W Harris
Aug 1, 1996·Journal of Hepatology·J P VilleneuveM Lefebvre
Jul 21, 1998·Annals of the New York Academy of Sciences·C HershkoI Cabantchik
Aug 3, 2000·The New England Journal of Medicine·E AngelucciG Lucarelli
Oct 6, 2000·Journal of Hepatology·P AdamsL W Powell
Nov 13, 2001·British Journal of Haematology·J B Porter
Nov 28, 2001·Hematology·J P KushnerN F Olivieri
Aug 31, 2002·Journal of Magnetic Resonance Imaging : JMRI·Maria I AltbachArthur F Gmitro
Oct 24, 2002·Blood·Gary M BrittenhamUNKNOWN National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Workshop
Jul 25, 2003·Magnetic Resonance Imaging·Paul R ClarkTimothy G St Pierre
May 7, 2004·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Paul R ClarkTimothy G St Pierre
Jul 17, 2004·Blood·Timothy G St PierreRobert Lindeman
Nov 4, 2004·NMR in Biomedicine·Timothy G St PierreWanida Chua-Anusorn
Feb 16, 2006·Archives of Internal Medicine·Lawrie W PowellMark L Bassett
Oct 4, 2006·Annual Review of Physiology·Nancy C Andrews, Paul J Schmidt
Jun 16, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel KimGary M Brittenham
Jun 22, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mariya DonevaAlfred Mertins
Sep 9, 2011·Seminars in Liver Disease·Eng K GanJohn K Olynyk
Apr 13, 2012·Magnetic Resonance Imaging·Olympia PapakonstantinouNikolaos L Kelekis
Oct 18, 2012·Annals of Hematology·F NolteH Schrezenmeier
Mar 15, 2013·Nature·Dan MaMark A Griswold
Jul 4, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tim G St PierreAli Taher
Dec 20, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Leon A AdamsJohn K Olynyk
Citations
Jun 5, 2019·Abdominal Radiology·Juan S Calle-ToroSuraj D Serai
Feb 13, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rohan KapreAngelique Y Louie
Dec 14, 2018·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Sarah Eskreis-WinklerLorenzo Mannelli
Apr 2, 2020·The Journal of International Medical Research·Yi ZhouBin Song