Inter-Organelle Membrane Contact Sites and Mitochondrial Quality Control during Aging: A Geroscience View.

Cells
Anna PiccaEmanuele Marzetti

Abstract

Mitochondrial dysfunction and failing mitochondrial quality control (MQC) are major determinants of aging. Far from being standalone organelles, mitochondria are intricately related with cellular other compartments, including lysosomes. The intimate relationship between mitochondria and lysosomes is reflected by the fact that lysosomal degradation of dysfunctional mitochondria is the final step of mitophagy. Inter-organelle membrane contact sites also allow bidirectional communication between mitochondria and lysosomes as part of nondegradative pathways. This interaction establishes a functional unit that regulates metabolic signaling, mitochondrial dynamics, and, hence, MQC. Contacts of mitochondria with the endoplasmic reticulum (ER) have also been described. ER-mitochondrial interactions are relevant to Ca2+ homeostasis, transfer of phospholipid precursors to mitochondria, and integration of apoptotic signaling. Many proteins involved in mitochondrial contact sites with other organelles also participate to degradative MQC pathways. Hence, a comprehensive assessment of mitochondrial dysfunction during aging requires a thorough evaluation of degradative and nondegradative inter-organelle pathways. Here, we present a geroscienc...Continue Reading

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Citations

May 16, 2020·Journal of Clinical Medicine·Anna PiccaEmanuele Marzetti
Aug 13, 2020·International Journal of Molecular Sciences·Anna PiccaEmanuele Marzetti
Nov 18, 2020·Cellular and Molecular Life Sciences : CMLS·Fei MengHaiming Dai
Sep 18, 2020·IScience·Pamela J YaoDimitrios Kapogiannis
Mar 7, 2021·Biomedicines·Nuno Santos Leal, Luís Miguel Martins
Mar 16, 2021·Current Opinion in Pharmacology·Anna PiccaEmanuele Marzetti
Jul 27, 2021·ASN Neuro·Bipul RayMeena Kishore Sakharkar
Aug 7, 2021·Experimental Gerontology·Anna PiccaEmanuele Marzetti

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Methods Mentioned

BETA
GTPase
GTPases
ubiquitination
optical microscopy

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