PMID: 7037336Jan 1, 1981Paper

Inter-relationship of sympathetic nervous system and renin-angiotensin-aldosterone system in three renin subgroups of borderline and persistent essential hypertension

Clinical and Experimental Hypertension : CHE
K MikamiA Kumagai

Abstract

Plasma renin activity (PRA), dopamine beta-hydroxylase (DBH) activity, and plasma aldosterone concentration were determined in 51 patients categorized as borderline or persistent hypertensives and as high, normal, or low renin. Basal DBH activity correlated with diastolic blood pressure in borderline but not in persistent hypertensives. In borderline patients with normal or high renin activity standing plus furosemide caused a marked rise in diastolic blood pressure but little change in systolic and increased PRA and DBA. In contrast this stimulation procedure depressed both systolic and diastolic blood pressure and resulted in blunted PRA and DBH responses in the low renin borderline and the three groups of persistent hypertensives. After dietary sodium restriction, the decrease in systolic blood pressure correlated with the decrease in urinary sodium excretion in persistent, but not in the borderline patients. The data suggest that both borderline an persistent hypertensive patients respond to volume depletion with an increase in sympathetic and renin activity, and the increase of these two vasoconstrictive systems is greater in borderline hypertensives.

References

Jan 1, 1978·Clinical and Experimental Hypertension : CHE·I EideV DeQuattro
Feb 24, 1977·The New England Journal of Medicine·M D EslerV DeQuattro
Nov 23, 1976·The American Journal of Cardiology·V DeQuattroD J Meijer
Oct 31, 1975·The American Journal of Cardiology·M D EslerT Kashima
Dec 1, 1975·Clinical Science and Molecular Medicine·J M AlexandreY Weiss

Citations

Apr 15, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masao OmuraTetsuo Nishikawa
Jan 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B Petersen

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