Inter-residue, inter-protein and inter-family coevolution: bridging the scales

Current Opinion in Structural Biology
Hendrik Szurmant, Martin Weigt

Abstract

Interacting proteins coevolve at multiple but interconnected scales, from the residue-residue over the protein-protein up to the family-family level. The recent accumulation of enormous amounts of sequence data allows for the development of novel, data-driven computational approaches. Notably, these approaches can bridge scales within a single statistical framework. Although being currently applied mostly to isolated problems on single scales, their immense potential for an evolutionary informed, structural systems biology is steadily emerging.

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Jan 20, 2018·Molecular Biology and Evolution·Matteo FigliuzziMartin Weigt
Aug 16, 2019·PLoS Computational Biology·Jacopo MarchiThierry Mora
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Oct 8, 2021·The Journal of Physical Chemistry. B·Kareem M MehrabianiJosé N Onuchic

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