PMID: 22574546May 12, 2012Paper

Inter-site validations of the Pixel-Wise method for cardiac T2* analysis in transfusion-dependent Thai thalassemia patients

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Pairash SaiviroonpornRungroj Krittayaphong

Abstract

To compare inter-site observer variability of the Pixel- Wise (PW) method for cardiac T2* analysis in thalassemia patients using the mono-exponential with a constant fitting (offset) model and to compare the cross-model variability of the offset model to the mono-exponential (typical) model. Eighty-eight cardiac T2* measurements were performed on 72 Thalassemia major patients. Both bright- and black-blood techniques were acquired and analyzed at both the reference (REF) and local (LOC) sites using the PW method by defined region of interest on the whole (at the REF site) and partial (at the LOC site) septum. The offset model was analyzed at the reference site while both the offset and typical models were performed at the local site. The inter-site variability of the T2* values were analyzed by independent observers blinded to the results. The T2* values from the REF-offset, LOC-offset and LOC-typical methods were statistically comparable on both scanning techniques. The inter-site variations of the offset model were about 5.2% and 4.4% on the bright- and black-blood techniques, respectively, which was about 1.7% higher than from the intra-site, but was still in a reasonable range compared to the conventional method of around 5....Continue Reading

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