Inter-slice leakage and intra-slice aliasing in simultaneous multi-slice echo-planar images

BioRxiv : the Preprint Server for Biology
Carolyn Beth McNabbTom Johnstone


Simultaneous multi-slice (SMS) imaging is a popular technique for increasing acquisition speed in echo-planar imaging (EPI) fMRI. However, SMS data are prone to motion sensitivity and slice leakage artefacts, which spread signal between simultaneously acquired slices. Relevant to motion sensitivity, artefacts from moving anatomic structures propagate along the phase-encoding (PE) direction. This is particularly relevant for eye movement. As signal from the eye is acquired along with signal from simultaneously excited slices during SMS, there is potential for signal to spread in-plane and between spatially remote slices. After identifying an artefact temporally coinciding with signal fluctuations in the eye and spatially distributed in correspondence with multiband slice acceleration and parallel imaging factors, we conducted a series of small experiments to investigate eye movement artefacts in SMS data and the contribution of PE direction to the invasiveness of these artefacts. Five healthy adult volunteers were scanned during a blinking task using a standard SMS-EPI protocol with posterior-to-anterior (P>>A), anterior-to-posterior (A>>P) or right-to-left (R>>L) PE direction. The intensity of signal fluctuations (artefact seve...Continue Reading

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Diagnostic Imaging
Eye Movements
Human Volunteers
Research Personnel
Echo-Planar Imaging

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