Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart.

Molecular & Cellular Proteomics : MCP
Tania Martins-MarquesHenrique Girao

Abstract

The coordinated and synchronized cardiac muscle contraction relies on an efficient gap junction-mediated intercellular communication (GJIC) between cardiomyocytes, which involves the rapid anisotropic impulse propagation through connexin (Cx)-containing channels, namely of Cx43, the most abundant Cx in the heart. Expectedly, disturbing mechanisms that affect channel activity, localization and turnover of Cx43 have been implicated in several cardiomyopathies, such as myocardial ischemia. Besides gap junction-mediated intercellular communication, Cx43 has been associated with channel-independent functions, including modulation of cell adhesion, differentiation, proliferation and gene transcription. It has been suggested that the role played by Cx43 is dictated by the nature of the proteins that interact with Cx43. Therefore, the characterization of the Cx43-interacting network and its dynamics is vital to understand not only the molecular mechanisms underlying pathological malfunction of gap junction-mediated intercellular communication, but also to unveil novel and unanticipated biological functions of Cx43. In the present report, we applied a quantitative SWATH-MS approach to characterize the Cx43 interactome in rat hearts subj...Continue Reading

References

Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·W C ClaycombN J Izzo
Oct 30, 2003·Omics : a Journal of Integrative Biology·Rajanikanth VadigepalliGregory E Gonye
May 28, 2005·Cardiovascular Research·Kerstin BoenglerRainer Schulz
Aug 3, 2006·Journal of Cell Science·Paul D LampeJanis M Burt
Apr 28, 2007·Progress in Biophysics and Molecular Biology·Elissavet KardamiDavid C Spray
May 4, 2007·Progress in Biophysics and Molecular Biology·Marc ChansonScott M O'Grady
Nov 21, 2007·Methods in Molecular Biology·Nicola Mulder, Rolf Apweiler
Dec 18, 2007·Bioinformation·Lokesh Kumar, Matthias E Futschik
May 6, 2008·Bioinformatics·Ashoka D PolpitiyaRichard D Smith
Aug 15, 2008·Journal of Proteome Research·Wilfred H TangSean L Seymour
Nov 11, 2008·Current Pharmaceutical Design·Giuseppe M C RosanoGiuseppe Barbaro
Jul 25, 2009·Histochemistry and Cell Biology·Irina V MajoulRainer Duden
Oct 20, 2009·Experimental Cell Research·Henrique GirãoPaulo Pereira
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Daniel A Goodenough, David L Paul
May 24, 2011·Molecular & Cellular Proteomics : MCP·Kristoffer T G RigboltBlagoy Blagoev
Dec 3, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Heather S Duffy
Dec 27, 2011·Biochimica Et Biophysica Acta·Jean-Claude HervéNicolas Bourmeyster
Jul 20, 2012·The Journal of Membrane Biology·J Matthew RhettRobert G Gourdie
Apr 18, 2013·Journal of Proteome Research·Stephanie L FowlerSteffany A L Bennett
Jul 26, 2013·Molecular Biology of the Cell·John T FongMatthias M Falk
Feb 20, 2014·FEBS Letters·Esperanza Agullo-PascualMario Delmar
Mar 1, 2014·Frontiers in Physiology·Stefan KurtenbachGeorg Zoidl
Apr 15, 2014·Nature Biotechnology·Juan A VizcaínoHenning Hermjakob
Jul 30, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Teresa M Ribeiro-RodriguesHenrique Girão
Nov 25, 2014·Proteomics·Sandra Isabel AnjoBruno Manadas
Dec 17, 2014·Proteomics·Eystein OvelandHarald Barsnes
Jan 22, 2015·The Biochemical Journal·Tania Martins-MarquesHenrique Girão
Mar 10, 2015·Biochimie·Tânia Martins-MarquesHenrique Girão
Apr 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Youn Wook ChungVincent C Manganiello
Apr 24, 2015·Molecular & Cellular Proteomics : MCP·Raquel Gago-FuentesMaria Dolores Mayan
May 27, 2015·Biochemical Society Transactions·Tânia Martins-MarquesHenrique Girão

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Citations

Feb 22, 2017·The Journal of Endocrinology·Hai-Fan YuBin Guo
Feb 18, 2018·Fundamental & Clinical Pharmacology·Nair AnupamaKozhiparambil Gopalan Raghu
Jul 14, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Kerstin BoenglerRainer Schulz
Jun 3, 2018·Acta Physiologica·K PogodaU Pohl
Oct 13, 2018·Nature Reviews. Drug Discovery·Dale W Laird, Paul D Lampe
Sep 22, 2017·Pharmacological Reviews·Luc LeybaertRainer Schulz
Aug 3, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Arnaud TantiNaguib Mechawar
Sep 12, 2019·Anatomical Science International·Shingo HirashimaKei-Ichiro Nakamura
Dec 17, 2019·Cardiovascular Research·Alessio LissoniLuc Leybaert
Jun 4, 2020·Journal of Cellular and Molecular Medicine·Derek J HausenloyFabio Di Lisa
May 12, 2018·International Journal of Molecular Sciences·Paul L SorgenMorten S Nielsen
Mar 7, 2020·Circulation Research·Tania Martins-MarquesHenrique Girão
Aug 28, 2020·Biomolecules·Olga M RusieckaBrenda R Kwak
Feb 13, 2020·Microscopy·Shingo HirashimaKei-Ichiro Nakamura
Nov 15, 2016·Expert Review of Proteomics·David W GreeningRichard J Simpson
Oct 25, 2020·Life Science Alliance·Tania Martins-MarquesHenrique Girao
Feb 15, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Shlok JindalGopinath Packirisamy
Mar 23, 2021·Basic Research in Cardiology·Christine HirschhäuserKerstin Boengler
May 1, 2021·International Journal of Molecular Sciences·Antonio Rodríguez-SinovasIgnacio Ferreira-González
Jun 4, 2021·Life Science Alliance·Garima SinhaPranela Rameshwar
Apr 24, 2017·Journal of Proteomics·Sandra I AnjoBruno Manadas

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