PMID: 8939724Oct 1, 1996Paper

Interacting signaling pathways controlling multicellular development in Dictyostelium

Current Opinion in Genetics & Development
R A Firtel

Abstract

cAMP functions as the key extracellular signaling molecule controlling Dictyostelium development acting through classic G-protein-coupled/serpentine receptors. Whereas aggregation is controlled by nanomolar pulses of cAMP, a more continuous micromolar signal controls multicellular differentiation by activating a transcriptional cascade via a receptor-mediated but non G-protein-coupled pathway. Potential mechanisms by which extracellular cAMP functions to differentially control aggregation followed by morphogenesis and cell-type differentiation are discussed. This review also summarizes new findings elucidating pathways controlling cell-type regulation in this organism, including signaling cascades mediated by glycogen synthase kinase 3 and cAMP-dependent protein kinase, key regulators of cell-type differentiation in metazoans, and newly identified transcription factors.

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D TraynorJ G Williams
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F Siegert, C J Weijer
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S K Mann, R A Firtel
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M FaureR H Kessin
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P J Van HaastertR Van Driel
Mar 17, 1995·The Journal of Biological Chemistry·J L MilneP N Devreotes
Aug 1, 1995·Current Biology : CB·F Siegert, C J Weijer
Feb 1, 1995·The Journal of Cell Biology·J E SegallW F Loomis
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·S K MannR A Firtel
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·J A HadwigerR A Firtel
Jun 1, 1994·Molecular Biology of the Cell·R H InsallP N Devreotes
Jan 1, 1994·Progress in Nucleic Acid Research and Molecular Biology·J Williams, A Morrison

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Citations

Jan 10, 2002·Cell Biology International·Akhilesh Kumar, Samar Chatterjee
Jul 4, 1998·Biophysical Chemistry·J HalloyA Goldbeter
Jul 4, 1998·Biophysical Chemistry·D DormannC J Weijer
Nov 10, 1998·Trends in Microbiology·F Söderbom, W F Loomis
Sep 2, 1999·Trends in Biochemical Sciences·J G Williams
Jan 6, 2001·Development, Growth & Differentiation·S Nagano
Jul 23, 2002·Molecular Biology of the Cell·Alexandre TaminatoGlaucia Mendes Souza
Dec 8, 1998·Molecular Biology of the Cell·M T Laub, W F Loomis
Aug 7, 1998·Molecular Biology of the Cell·E L de HostosR D Vale
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D DormannC J Weijer
Dec 28, 1999·Annual Review of Cell and Developmental Biology·L Aubry, R Firtel
Jul 31, 2010·BMC Developmental Biology·Luciana MantzouranisGlaucia M Souza
Jun 16, 2014·Cell Communication and Signaling : CCS·Napoleon Nosa OmosighoTanja Y Riyahi
Dec 2, 2000·Differentiation; Research in Biological Diversity·K NatarajanJ A Hadwiger
Apr 15, 2014·Developmental Biology·William F Loomis
Jan 22, 2000·Developmental Biology·J M Brown, R A Firtel
Jan 21, 2004·Developmental Biology·Brent RaisleyJeffrey A Hadwiger
Jul 14, 1999·Developmental Genetics·J T StegeW F Loomis
Sep 17, 1999·The Journal of Biological Chemistry·P A ThomasonR R Kay
Nov 24, 1999·The Journal of Biological Chemistry·W J Deery, R H Gomer

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