Interaction Among Sex, Aging, and Epigenetic Processes Concerning Visceral Fat, Insulin Resistance, and Dyslipidaemia

Frontiers in Endocrinology
Ana ArpónJ Alfredo Martínez

Abstract

The distribution of adipose tissue is influenced by gender and by age, shifting from subcutaneous to visceral depots with longevity, increasing the development of several aging-related diseases and manifestations such as obesity, metabolic syndrome, and insulin resistance. Epigenetics might have an important role in aging processes. The aim of this research was to investigate the interactions between aging and epigenetic processes and the role of visceral adipose tissue, insulin resistance, and dyslipidaemia. Two different study samples of 366 and 269 adult participants were analyzed. Anthropometric, biochemical (including the triglycerides-glucose (TyG) index), and blood pressure measurements were assessed following standardized methods. Body composition measurements by Dual-energy X-ray absorptiometry (DXA) were also performed for the second sample. Methylation data were assessed by Infinium Human Methylation BeadChip (Illumina) in peripheral white blood cells. Epigenetic age acceleration was calculated using the methods DNAmAge (AgeAcc) and GrimAge (AgeAccGrim). Age acceleration (AgeAccGrim) showed better correlations than AgeAcc with most of the measured variables (waist circumference, glucose, HOMA-IR, HDL-cholesterol, tri...Continue Reading

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Citations

Oct 8, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jamaji C Nwanaji-EnweremJoel Schwartz
Jul 1, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Markus RohnerStefan R Bornstein
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Jun 26, 2021·The European Journal of Neuroscience·Jacqueline S WomersleySîan M J Hemmings

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Datasets Mentioned

BETA
GSE115278

Methods Mentioned

BETA
histone acetylation
X-ray

Software Mentioned

Food4Me
ChAMP package for R
CoreScan
OBEPALIP
NUGENOB
PhenoAge
ICTUS
DiOGenes
DNAmAge
enCORE

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