Interaction between adrenaline and epidermal growth factor in the control of liver glycogenolysis in mouse

Endocrinology
M GrauI Ramírez

Abstract

Epidermal growth factor (EGF) stimulates glycogenolysis in mouse liver, but the effect requires concentrations that are only achieved in plasma upon adrenergic stimulation of EGF release from submandibular salivary glands. Thus, we studied the interaction between adrenaline and EGF in liver glycogen metabolism, both in whole animals and in isolated hepatocytes. Adrenaline administered to anesthetized mice stimulated both the endocrine secretion of EGF from submandibular salivary glands and the degradation of glycogen in the liver. In sialoadenalectomized mice, adrenaline administration did not increase plasma EGF concentration. In these animals, the glycogenolytic response to adrenaline was enhanced. The sensitivity of hepatocytes to adrenaline was similar in cells from sialoadenalectomized and sham-operated mice. EGF, added to isolated hepatocytes, reduced the glycogenolytic effect of adrenaline (the maximal effect but not the ED50). Adrenaline stimulated glycogen degradation through both an alpha1-adrenergic mediated Ca2+ increase and a beta-adrenergic-mediated cAMP increase. EGF did not interfere with the rise of cytosolic Ca2+ but decreased the cAMP signal. EGF did not decrease the glycogenolytic effect of phenylephrine or ...Continue Reading

Citations

Apr 24, 2009·Anti-cancer Drugs·Hussein A Al-WadeiHildegard M Schuller
Oct 26, 2000·Cell Stress & Chaperones·G FernándezI Ramírez
Mar 15, 2002·Cell Stress & Chaperones·Olga SánchezMaria Soley
Feb 12, 2010·Future Oncology·Hildegard M Schuller, Hussein An Al-Wadei
Oct 30, 2003·Journal of Cellular Physiology·Irma BuiraMaria Soley
Mar 19, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Olga SánchezMaria Soley
Dec 2, 2017·International Journal of Cancer. Journal International Du Cancer·Yuzhuo WangHongbing Shen
Dec 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·Loubna Erraji-BenchekrounClaudine André
Nov 2, 2007·Glycoconjugate Journal·M Carmen LouzaoLuis M Botana
Feb 6, 2009·Nature Reviews. Cancer·Hildegard M Schuller
Jul 18, 2019·Expert Review of Respiratory Medicine·Hildegard M Schuller
Jan 11, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lawrence A SchevingWilliam E Russell
Sep 18, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xavier GalanIgnasi Ramírez
Apr 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miguel ParejaIgnasi Ramírez
Sep 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Olga SánchezMaria Soley
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jordi LoritaIgnasi Ramírez
Aug 22, 2021·Nature Communications·Maria J Gonzalez-RellanRuben Nogueiras

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