PMID: 3765344Jun 1, 1986Paper

Interaction between Aeromonas salmonicida and peritoneal macrophages of brook trout (Salvelinus fontinalis)

Veterinary Immunology and Immunopathology
G OlivierN Campbell

Abstract

The phagocytic and bactericidal properties of peritoneal macrophages obtained from brook trout (Salvelinus fontinalis), injected with either glycogen or a modified Freund's complete adjuvant (MFCA), were evaluated against an avirulent and a virulent strain of Aeromonas salmonicida. Avirulent bacteria were effectively phagocytized and killed by macrophages obtained from fish injected with both irritants. With glycogen-elicited macrophages, no enhancement of killing was observed following opsonization of avirulent bacteria with specific antibodies. A killing index (K.I.) of 38 was obtained, compared to a K.I. of 39 for unopsonized bacteria. When avirulent bacteria were opsonized with complement, the K.I. was increased to 67. Virulent bacteria were less susceptible to the phagocytic and the bactericidal activities of glycogen-elicited macrophages, even after opsonization with antibodies and/or complement, K.I. of 9 to 15. In contrast, MFCA-elicited macrophages showed increased phagocytic and bactericidal activities against both strains. The K.I. of unopsonized virulent bacteria was increased to 47 and 46 compared to K.I. of 4 and 7 obtained with glycogen-elicited macrophages.

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Citations

Jan 1, 1990·Developmental and Comparative Immunology·J F SövényiR Kusuda
Jan 1, 1990·Developmental and Comparative Immunology·A J Ainsworth, D X Chen
Jan 1, 1992·Developmental and Comparative Immunology·G OlivierJ Fildes
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Aug 6, 2013·Fish & Shellfish Immunology·Tomáš KorytářBernd Köllner
Apr 12, 2002·Veterinary Immunology and Immunopathology·Scott PeddieChristopher J Secombes
Dec 19, 2013·North American Journal of Medical Sciences·Vaclav VetvickaPetr Sima
Aug 21, 2013·In Vitro Cellular & Developmental Biology. Animal·Sanjay C RebelloV Elangovan
Aug 27, 2002·Fish & Shellfish Immunology·M Claire H Holland, John D Lambris
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Feb 1, 1996·Immunopharmacology and Immunotoxicology·N BennaniM Lafaurie
Jun 26, 2020·Frontiers in Immunology·Kristen A ByrneJodi L McGill
Jun 13, 2018·Frontiers in Immunology·Leon GrayferMiodrag Belosevic
Nov 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marianna V RodriguesVaclav Vetvicka
Oct 1, 1992·Infection and Immunity·R A GarduñoW W Kay

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