Interaction Between AGTR1 and PPARγ Gene Polymorphisms on the Risk of Nonalcoholic Fatty Liver Disease

Genetic Testing and Molecular Biomarkers
Peifu ZhuChen Dong

Abstract

Nonalcoholic fatty liver disease (NAFLD) is an important public health issue worldwide. Several recent studies have reported that peroxisome proliferator-activated receptor-γ (PPARγ) and angiotensin II type 1 receptor (AGTR1) variants are associated with NAFLD occurrence, but the results have been inconsistent. The aim of this study was to analyze the interactions between PPARγ and AGTR1 polymorphisms and their associations with NAFLD in Chinese adults. Seven single nucleotide polymorphisms (SNPs) of the PPARγ gene and 5 SNPs of the AGTR1 gene were selected and genotyped in 1591 unrelated Chinese adults. The SNPAssoc package of R was used to examine the relationships between the selected SNPs and NAFLD. After adjusting the covariance, the results from the overdominant model showed that participants carrying the T/C genotype of rs2638360 in AGTR1 have a decreased risk of NAFLD compared with those with T/T-C/C genotypes (odds ratio: 0.70, 95% confidence interval: 0.49-1.00). However, our results showed that none of the selected PPARγ variants were significantly associated with the risk of NAFLD after applying a false discovery rate correction. Among the 12 selected SNPs from PPARγ and AGTR1, model-based multifactor dimensionality...Continue Reading

References

Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshijiH Fukui
Sep 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shiro YokohamaKimihide Nakamura
Mar 24, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Masato YonedaAtsushi Nakajima
Jan 16, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Montserrat MorenoRamón Bataller
Sep 8, 2010·European Journal of Internal Medicine·Lucia Maria ProcopciucDumitru Zdrenghea
Jan 20, 2015·Experimental and Molecular Pathology·Paola León-MimilaSamuel Canizales-Quinteros
Dec 19, 2015·Journal of Diabetes Research·Siew Mei Joyce-TanNor Azizan Abdullah
Apr 12, 2016·Clinics in Liver Disease·Kristina R Chacko, John Reinus
Oct 18, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C BorghiA F Cicero
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Stefano Bellentani
Mar 3, 2017·European Journal of Gastroenterology & Hepatology·Ahmet UygunBelkis Unsal
Nov 1, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·X XieC Meyer
Dec 22, 2017·Genetic Testing and Molecular Biomarkers·Xiaoyan QianChen Dong

❮ Previous
Next ❯

Citations

Jul 24, 2020·Molecular Medicine·Xian ShiGuo-Jun Zhao
May 1, 2021·International Journal of Molecular Sciences·Siarhei A DabravolskiAlexander N Orekhov
Jun 10, 2021·American Journal of Hypertension·Yang JingChen Dong

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
biopsy

Software Mentioned

R
MB
MDR
SNPAssoc

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.