PMID: 8594034Nov 1, 1995Paper

Interaction between airway lining fluid forces and parenchymal tethering during pulmonary airway reopening

Journal of Applied Physiology
M L Perun, D P Gaver

Abstract

In this study, our goal is to identify the interaction between airway lining fluid viscous and surface forces and parenchymal tethering forces during pulmonary airway reopening. The type of closure we modeled occurs when the airway walls and surrounding parenchyma collapse and are held in apposition by the lining fluid. We mimicked this system with a polyethylene tube coated with a Newtonian lining fluid supported by open-cell foam. Reopening occurs when a finger of air travels through the collapsed region. We measured the airway pressure (Paw) required to open the airway at a constant velocity (U). Increasing the foam stiffness (K), lining fluid viscosity (mu), and surface tension (gamma) results in an increase in Paw. Furthermore, increasing the downstream suction pressure (Pds), through tethering, causes an equivalent reduction in Paw. The upstream radius is the primary length scale, and fluid forces are represented by the capillary number: Ca = microU/gamma. On the basis of these results, we predicted the likelihood that tethering would begin to reopen collapsed airways in various disease states. This analysis showed that the ratio of tethering to fluid forces determines airway patency, which is defined as follows: lambda =...Continue Reading

Citations

Aug 1, 1997·Journal of Biomechanical Engineering·H T LowC W Zhou
Apr 12, 2001·Journal of Applied Physiology·M A MartynowiczR D Hubmayr
Dec 9, 2003·Journal of Applied Physiology·Scott WagersJason H T Bates
Apr 20, 2004·Journal of Applied Physiology·Z HantosB Suki
Apr 2, 2005·Journal of Applied Physiology·Shailesh Naire, Oliver E Jensen
Jan 5, 2011·Annals of Biomedical Engineering·Adrian S SeahJason H T Bates
Mar 5, 2011·Journal of Applied Physiology·Baoshun MaJason H T Bates
Dec 10, 2016·Journal of Applied Physiology·Christian J RothWolfgang A Wall
Feb 28, 2004·Journal of Biomechanical Engineering·S Naire, O E Jensen
Aug 1, 2009·Experiments in Fluids·Eiichiro YamaguchiDonald P Gaver
Jun 17, 2010·Annals of Biomedical Engineering·Baoshun Ma, Jason H T Bates
Sep 15, 2020·Frontiers in Physiology·Haoran MaDonald P Gaver
Aug 17, 2002·Journal of Applied Physiology·Samir N GhadialiJ Douglas Swarts
Oct 29, 2000·Journal of Applied Physiology·B SukiZ Hantos
Oct 25, 2008·Journal of Applied Physiology·Christopher B MassaJason H T Bates
Dec 17, 2008·Journal of Fluid Mechanics·Bradford J Smith, Donald P Gaver
Nov 20, 2012·Annals of Biomedical Engineering·Bradford J SmithJason H T Bates
Oct 11, 2008·Journal of Applied Physiology·Z HantosB Suki
Jan 4, 2006·Annals of Biomedical Engineering·Chris D Bertram, Donald P Gaver
Jan 1, 2012·Scientifica·Sanjeev Kumar MahtoJosué Sznitman
Aug 26, 2009·Physics of Fluids·Y ZhengJ B Grotberg
May 7, 2005·Respiratory Physiology & Neurobiology·Kevin M EllyettRoland S Broadbent
May 31, 2008·Respiratory Physiology & Neurobiology·Samir N Ghadiali, Donald P Gaver

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