Interaction between aldosterone and renomedullary prostaglandins. Competitive action between aspirin and spironolactone

N PapanicolaouP Milliez


Aldosterone injected i.m. decreased the release of renomedullary PGEs and the index (urinary Na/K ratio) in conscious normotensive intact and adrenalectomized rats. Coadministration of spironolactone increased the release of PGEs as well as the index (urinary Na/K ratio). The effect of spironolactone was partly inhibited by aspirin injected in a ratio 5:1 (aspirin:spironolactone), and effect which could be reversed by the infusion of a synthetic prostaglandin (PGA2) in a subhypotensive dose.


Sep 1, 1975·The Journal of Pharmacy and Pharmacology·N Papanicoulaou
Feb 28, 1977·Documenta Ophthalmologica. Advances in Ophthalmology·P B Wilhelm, G W Alphen
Nov 1, 1975·Clinical Science and Molecular Medicine·N PapanicolaouP Milliez
Apr 8, 1972·British Medical Journal·M W Greaves, W McDonald-Gibson
Mar 15, 1972·Experientia·N Papanicolaou
Oct 1, 1967·The American Journal of Physiology·H H JohnstonD P Lauler


Dec 1, 1992·Hypertension·C L Jackson, S M Schwartz
May 1, 1981·Postgraduate Medical Journal·M J VandenBurgF P Marsh
Jan 1, 1980·Acta Pharmacologica Et Toxicologica·T DavilaE Anggård

Related Concepts

Aldosterone, (+-)-Isomer
Prostaglandins A, Synthetic
Prostaglandins E
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Rats, Laboratory

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