Interaction between alpha 1 antitrypsin and lymphocyte surface proteases: immunoregulatory effects

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J Bata, J P Revillard

Abstract

Alpha 1 antitrypsin (alpha 1-AT) is the major plasma protease inhibitor. Radioiodinated alpha 1-AT binds to human lymphocytes. The binding is fast and reversible, and the cells can be saturated with a maximum of approximately 1.2 x 10(6) molecules of alpha 1-AT per lymphocyte. The receptor for alpha 1-AT is a surface-associated protease. Addition of alpha 1-AT completely inhibits cell surface proteolytic activity. Furthermore alpha 1-AT decreases 3H-thymidine incorporation into lymphocytes stimulated by B or T cell mitogens or by allogeneic cells. Since alpha 1-AT was shown to be produced by activated monocytes and to bind to lymphocytes, it is likely to represent a mediator of monocyte-lymphocyte interactions.

References

Apr 15, 1978·Experientia·A W ThomsonC H Horne
Aug 10, 1978·Nature·P K AroraL D Aronson
Oct 1, 1976·The Journal of Experimental Medicine·T L VischerM Baggiolini
Aug 1, 1976·Experimental Cell Research·L B ChenJ M Buchanan
Oct 15, 1976·Experimental Cell Research·D A Hart, J S Streilein
Jan 1, 1976·Scandinavian Journal of Immunology·C SamarutJ P Revillard
Oct 15, 1976·Experimental Cell Research·D A Hart, J S Streilein
Oct 2, 1976·Schweizerische medizinische Wochenschrift·U BretzT L Vischer
Mar 30, 1974·Experimental Cell Research·Z Darzynkiewicz, B G Arnason
Jan 1, 1980·Biulleten' eksperimental'noĭ biologii i meditsiny·F S BaranovaIu M Zaretskaia
Feb 12, 1981·Biochemical and Biophysical Research Communications·J BataJ P Revillard
May 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·G B WilsonD Wolgroch

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Citations

Mar 1, 1991·Immunology Today·A Stadnyk, J Gauldie
Jul 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Jerzy W NaskalskiRyszard Drozdz
Jun 1, 1984·Immunology Today·P K Donnelly, B K Shenton
Jul 1, 1983·Medical Hypotheses·W F Long, F B Williamson
Jun 1, 1984·Biochemical Pharmacology·D A Lewis
Apr 3, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mel BergerMaria Koulmanda
Nov 15, 2019·Transplantation Direct·Amir M EmtiazjooMark L Brantly
Nov 20, 2020·International Journal of Molecular Sciences·Jeong-Hoon LimChan-Duck Kim

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