PMID: 8603094Mar 13, 1996Paper

Interaction between alpha-tocopherol and heteroacid phosphatidylcholines with different amounts of unsaturation

Biochimica Et Biophysica Acta
M P Sánchez-MigallónJ C Gómez-Fernández

Abstract

Differential scanning calorimetry was used to study the influence of a alpha-tocopherol on the thermotropic properties of model membranes composed by a series of heteroacid phosphatidylcholines with different amount of unsaturation in the sn-2 chain. The effect of alpha-tocopherol on 1,2-distearoylglycerophosphocholine (18:0,18:0), 1-stearoyl-2-oleoylgylcerophosphocholine (18:0,18:1), 1-stearoyl-2-linoleoylglycerophosphocholine (18:0,18:2), 1-stearoyl-2-linolenoylglycerophosphocholine (18:0,18:3), and 1-stearoyl-2-arachidonoylglycerophosphocholine (18:0,20:4) was determined. The addition of alpha-tocopherol perturbed the thermotropic gel to liquid-crystalline phase transition of these phospholipids. alpha-Tocopherol broadened the endotherm, lowered the transition temperature and decreased the associated enthalpy change. Partial phase diagrams showed the presence of fluid immiscibilities giving rise to lateral phase separation of domains containing different amounts of alpha-tocopherol. We suggest that, in these alpha-tocopherol-rich domains, the influence exerted by the vitamin on the phospholipids is strong enough to alter their thermotropic properties such that an additional endotherm appears in the thermogram, a characterist...Continue Reading

References

Aug 9, 1977·Biochimica Et Biophysica Acta·A G Lee
Apr 13, 1992·Biochimica Et Biophysica Acta·W StillwellS R Wassall
Feb 28, 1990·Biochimica Et Biophysica Acta·V MicolJ C Gómez-Fernández
Jan 1, 1989·Annals of the New York Academy of Sciences·J C Gomez-FernandezM J Prieto
Jun 1, 1988·Chemistry and Physics of Lipids·F Severcan, S Cannistraro
Jan 31, 1989·Biochemical and Biophysical Research Communications·R H Bisby, D J Birch
Oct 1, 1986·Journal of Nutritional Science and Vitaminology·E J McMurchie, G H McIntosh
Aug 14, 1987·Biochemical and Biophysical Research Communications·S UranoM Matsuo
May 14, 1985·Biochimica Et Biophysica Acta·A N ErinV E Kagan
Dec 18, 1972·Annals of the New York Academy of Sciences·A L Tappel
Dec 18, 1972·Annals of the New York Academy of Sciences·L A Witting
Jun 15, 1982·Biochemical and Biophysical Research Communications·J B MasseyH J Pownall
Nov 1, 1993·Archives of Biochemistry and Biophysics·J SalgadoJ C Gómez-Fernández
Dec 12, 1993·Biochimica Et Biophysica Acta·J Hernandez-Borrell, K M Keough
Feb 1, 1973·FEBS Letters·A T. Diplock, J A. Lucy

❮ Previous
Next ❯

Citations

Dec 19, 2009·Cell Biochemistry and Biophysics·Alexander KoshkaryevSaul Yedgar
Feb 14, 2002·Chemistry and Physics of Lipids·Xiaoyuan Wang, Peter J Quinn
Jun 6, 2002·Chemistry and Physics of Lipids·Rumiana Koynova, Martin Caffrey
May 7, 1998·Chemistry and Physics of Lipids·A Grau, A Ortiz
Jul 4, 2012·Biochimica Et Biophysica Acta·Md Arif Kamal, V A Raghunathan
Nov 25, 1998·Biophysical Journal·J B Massey, H J Pownall
Dec 28, 2007·Free Radical Biology & Medicine·Jeffrey AtkinsonRichard M Epand
Feb 19, 2010·Molecular Nutrition & Food Research·Jeffrey AtkinsonJohn Katsaras
Jul 13, 2017·European Biophysics Journal : EBJ·Alexander L RabinovichDmitrii V Zhurkin
Mar 27, 1999·European Journal of Biochemistry·J C Gómez-FernándezF J Aranda
Jan 14, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Alessio AusiliJuan C Gomez-Fernández
Sep 18, 2008·The Journal of Physical Chemistry. B·Alessio AusiliJuan C Gómez-Fernández
Aug 24, 2001·Chemistry and Physics of Lipids·G G McManusH C Jarrell
Feb 16, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Alessio AusiliJuan C Gómez-Fernández

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.