PMID: 11341940May 9, 2001Paper

Interaction between alphaB-crystallin and the human 20S proteasomal subunit C8/alpha7

Biochimica Et Biophysica Acta
Wilbert C BoelensWilfried W de Jong

Abstract

alphaB-Crystallin, a member of the small heat shock protein (sHsp) family, can bind unfolding proteins, but is unable to refold them. To fulfil its protective function in vivo it is therefore likely to interact with other cellular proteins. Here we report that alphaB-crystallin binds very specifically both in vitro and in vivo to C8/alpha7, one of the 14 subunits of the 20S proteasome. The C8/alpha7 protein forms heterogeneous complexes with alphaB-crystallin of about 540 kDa. However, no strong interaction between alphaB-crystallin and 20S proteasomes was observed. Since both proteins are localized in the cytoplasm, the interaction between alphaB-crystallin and C8/alpha7 subunit might affect the assembly of the proteasome complex or facilitate the degradation of unfolded proteins bound to alphaB-crystallin.

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Citations

Feb 20, 2002·Journal of Molecular and Cellular Cardiology·Pauline VerschuureWilbert C Boelens
Feb 20, 2002·Journal of Molecular and Cellular Cardiology·Mark A Sussman
Sep 15, 2004·Toxicology and Applied Pharmacology·Jian-Ya HuanDennis R Koop
May 6, 2003·Biochemical and Biophysical Research Communications·Arnaud ParcellierCarmen Garrido
Dec 22, 2006·Molecular Biology of the Cell·Annette AhnerJeffrey L Brodsky
Jan 9, 2009·Human Molecular Genetics·Tracy L HagemannAlbee Messing
Mar 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roy A Quinlan, R John Ellis
Aug 5, 2003·Molecular and Cellular Biology·Arnaud ParcellierCarmen Garrido
Mar 5, 2002·Microbiology and Molecular Biology Reviews : MMBR·Franz Narberhaus
Oct 17, 2002·Cell Stress & Chaperones·Nicole Mounier, André-Patrick Arrigo
Jun 28, 2015·Biochimica Et Biophysica Acta·Martin HaslbeckSevil Weinkauf
May 24, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·André-Patrick Arrigo, Benjamin Gibert
Dec 15, 2006·Progress in Retinal and Eye Research·Usha P Andley
Apr 13, 2004·Journal of Cell Science·Yoshinobu FujitaYoriko Atomi
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