PMID: 9416731Jan 7, 1998Paper

Interaction between anesthetics and the sodium-hydrogen exchange inhibitor HOE 642 (cariporide) in ischemic and reperfused rat hearts

Anesthesiology
S Mathur, M Karmazyn

Abstract

Sodium (Na+)-hydrogen (H+) exchange (NHE) inhibitors are effective cardioprotective agents. The potent NHE inhibitor HOE 642 (cariporide) is being evaluated clinically in high-risk patients, including those having coronary artery bypass. Volatile anesthetics are also cardioprotective, most likely via different mechanisms. The potential interaction between anesthetics and HOE 642 was investigated. Electrically paced isolated rat hearts were perfused at constant flow. Left ventricular developed pressure and end-diastolic pressure were monitored as determinants of function. Hearts were subjected to 60 min each of total ischemia followed by reperfusion. Isoflurane (0.93 minimum alveolar concentration [MAC]), sevoflurane (1.03 MAC), or sufentanil (1.2 nM) was added 15 min before ischemia and throughout reperfusion, either alone or in combination with HOE 642 (5 microM). The effect of HOE 642 alone was also studied. At the end of reperfusion, hearts were freeze-clamped for subsequent determination of tissue metabolites. In control hearts, left ventricular developed pressure recovered to 40% of preischemia values, whereas left ventricular end-diastolic pressure increased by 650% after reperfusion. Sevoflurane, isoflurane, or HOE 642 a...Continue Reading

References

Dec 1, 1991·Anesthesia and Analgesia·A CoetzeeA Lochner
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Jan 1, 1995·Journal of Molecular and Cellular Cardiology·G N Pierce, M P Czubryt
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Citations

Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Manuel CastelláLouis J Ignarro
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David F StowePierre Schelling
Apr 10, 2002·Anaesthesia·N M AgnewG N Russell
May 28, 2005·Anesthesia and Analgesia·Stefan G De HertDavid F Stowe
Nov 4, 2000·Expert Opinion on Investigational Drugs·M Karmazyn
Aug 4, 2006·Journal of Cardiothoracic and Vascular Anesthesia·Takae KawamuraKatsuya Inada
Dec 11, 1999·Journal of Molecular and Cellular Cardiology·M Hartmann, U K Decking
Nov 26, 2002·The Journal of Thoracic and Cardiovascular Surgery·Manuel CastelláLouis J Ignarro
Sep 25, 2003·British Journal of Anaesthesia·M ZauggM C Schaub
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K KusumotoM Karmazyn
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Marija Tonkovic-CapinJohn E Baker
Feb 10, 1999·The American Journal of Physiology·R A HumphreysM Karmazyn

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