Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model

Brain, Behavior, and Immunity
Yuying TangWei Huang

Abstract

Accumulation of microglia occurs in the dorsal horn in the rodent model of chronic post ischemic pain (CPIP), while the mechanism how microglia affects the development of persistent pain largely remains unknown. Here, using a rodent model of CPIP induced by ischemia-reperfusion (IR) injury in the hindpaw, we observed that microglial accumulation occurred in the ipsilateral dorsal horn after ischemia 3h, and in ipsilateral and contralateral dorsal horn in the rats with ischemia 6h. The accumulated microglia released BDNF, increased neuronal excitability in dorsal horn, and produced pain behaviors in the modeled rodents. We also found significantly increased signaling mediated by astrocytic colony-stimulating factor-1 (CSF1) and microglial CSF1 receptor (CSF1R) in dorsal horn in the ischemia 6h modeled rats. While exogenous M-CSF induced microglial activation and proliferation, BDNF production, neuronal hyperactivity in dorsal horn and behavioral hypersensitivity in the naïve rats, inhibition of astrocytic CSF1/microglial CSF1R signaling by fluorocitric or PLX3397 significantly suppressed microglial activation and proliferation, BDNF upregulation, and neuronal activity in dorsal horn, as well as the mechanical allodynia and therm...Continue Reading

Citations

Jan 10, 2019·Frontiers in Cellular Neuroscience·Zhiming LiuJun-Ming Zhang
Mar 21, 2020·Frontiers in Molecular Neuroscience·Liquan WuLijuan Gu
Jun 6, 2018·Frontiers in Cellular Neuroscience·Céline MeriauxGommert A van Koeveringe
Oct 25, 2020·Cell Death & Disease·Nellwyn HaganDimitry Ofengeim
Feb 19, 2021·Journal of Leukocyte Biology·Antoine FreuchetIgnacio Anegon
Apr 1, 2021·Journal of Neuroinflammation·Ruixiang ChenBoyi Liu

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