Interaction between brain-derived neurotrophic factor Val66Met polymorphism and recent negative stressor in harm avoidance

Neuropsychobiology
Seog Ju KimHeon-Jeong Lee

Abstract

There have been controversial results regarding the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm avoidance (HA). We aimed to investigate the interaction between BDNF Val66Met polymorphism and negative life stressors in HA. BDNF Val66Met polymorphism was genotyped in 391 community-dwelling Koreans (152 males, 239 females; 43.2 +/- 14.1 years old). The Temperament and Character Inventory (TCI) and the Center for Epidemiological Studies for Depression Scale (CES-D) were self applied. The Structured Clinical Interview for DSM-IV axis I disorders and face-to-face interviews investigating negative life stressors within the last 6 months were also performed. There was no significant difference in TCI score, major depressive disorder prevalence and CES-D score among the 3 genotypes (94 Met/Met, 188 Val/Met and 109 Val/Val subjects). There was no significant difference in TCI scores between subjects with stressors and those without stressors, while more common major depressive episodes (p = 0.03) and higher CES-D scores (p < 0.001) were found in subjects with stressors. However, there was a significant interaction between the BDNF genotype and negative life st...Continue Reading

Citations

Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hui YuZhe-Yu Chen
Feb 6, 2013·Asian Journal of Psychiatry·Chirayu D PandyaAnilkumar Pillai
Jan 8, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kelli LehtoJaanus Harro
Dec 1, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Tetsuya AndoUNKNOWN Japanese Genetic Research Group For Eating Disorders
Nov 28, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Joseph P GyekisJingyun Yang
Dec 1, 2011·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Jin-Sung ParkKang-Seob Oh
Aug 12, 2021·CNS Spectrums·Clara MarincowitzDan J Stein

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