Interaction between cerebrovascular disease and Alzheimer pathology

Current Opinion in Psychiatry
Satoshi Saito, Masafumi Ihara

Abstract

Epidemiological investigations have proposed strict control of vascular risk factors as a strategy to overcome dementia, because of the close interaction between cerebrovascular disease (CVD) and Alzheimer's disease. In light of recent advances in basic, translational, and clinical research in the area, this review focuses on the significance of CVD in Alzheimer's disease pathogenesis. Alzheimer's disease and CVD share several risk factors, and the coexistence of both pathologies is frequently noted. CVD and subsequent cerebral blood flow reduction would increase amyloid β (Aβ) production by modulating β and γ-secretase. Furthermore, CVD impairs Aβ clearance, which is mainly driven by vascular mediated systems, including active transport across the blood-brain barrier, and perivascular lymphatic/paravascular glymphatic drainage systems. Thus, CVD may disturb homeostasis between Aβ production and clearance, thereby aggravating Alzheimer's disease. Recent translational researches in this field aim to facilitate Aβ clearance. Several candidate drugs are being tested in clinical trials. Compared with Aβ pathology, little is known about the relationship between tau pathology and CVD, although some studies have shown that CVD has an ...Continue Reading

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Apr 26, 2018·Dementia and Geriatric Cognitive Disorders·Julius S NgwaUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
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Methods Mentioned

BETA
transgenic

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