PMID: 9630512Jun 19, 1998Paper

Interaction between corticotropin-releasing factor and nitric oxide in mediating the response of the rat hypothalamus to immune and non-immune stimuli

Brain Research. Molecular Brain Research
S Lee, C Rivier

Abstract

We sought to determine whether nitric oxide (NO) influences the steady-state gene expression of corticotropin-releasing factor (CRF) in the paraventricular nucleus (PVN) of the rat hypothalamus and conversely, whether CRF alters the activity of PVN neurons containing NO synthase (NOS), the enzyme responsible for NO formation. Adult male rats exposed to a 30-min session of mild electrofootshocks displayed a significant (P<0.01) increase in mRNA levels of the immediate early gene NGFI-B in the parvocellular portion of the PVN, which contains neurons expressing CRF. This response was decreased (P<0.01) by pretreatment with l-NAME, an arginine derivative that blocks NOS activity. In contrast, the stimulatory effect of interleukin-1beta (IL-1beta), injected intracerebroventricularly (i.c.v.) 45 and 15 min earlier, on NGFI-B mRNA and CRF hnRNA levels, was not. The i.c.v. injection of CRF (1 microg) significantly upregulated transcription of the neuronal isoform of NOS in the PVN, while the ability of i.c.v. IL-1beta to stimulate this signal was not significantly altered by i.c.v. injection of CRF antagonists. These results indicate that even though CRF acts centrally to increase PVN NOS mRNA concentrations, this peptide is not requir...Continue Reading

References

Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·J GulyasJ Rivier
Jan 1, 1994·Progress in Neurobiology·S R Vincent
Jan 1, 1994·Sheng li ke xue jin zhan [Progress in physiology]·J Q CuiH X Wagn
Jul 1, 1994·British Journal of Pharmacology·D Minc-GolombJ P Schwartz
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·J M Fukuto, G Chaudhuri
Mar 1, 1995·Journal of Chemical Neuroanatomy·S Vanhatalo, S Soinila
Apr 1, 1995·Frontiers in Neuroendocrinology·C Rivier
Oct 1, 1993·Journal of Medicinal Chemistry·J F HernandezJ Rivier
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S KaranthS M McCann
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·H Y LiP E Sawchenko
Jan 27, 1997·The Journal of Comparative Neurology·T L Krukoff, P Khalili
Apr 1, 1993·Molecular and Cellular Neurosciences·G TorresC Rivier

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Citations

Jul 17, 1999·Brain Research. Brain Research Reviews·T L Krukoff
Jun 10, 2003·Annals of the New York Academy of Sciences·Catherine Rivier
Sep 25, 2003·Alcoholism, Clinical and Experimental Research·Soon Lee, Catherine Rivier
Jan 6, 2009·Annals of the New York Academy of Sciences·Nela MonasterioTeresa Morales
Mar 1, 2001·Stress : the International Journal on the Biology of Stress·C Rivier
Oct 3, 2001·Physiological Reviews·H E de Wardener
Jun 26, 2003·Alcoholism, Clinical and Experimental Research·Soon LeeCatherine Rivier

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