Interaction between D2 dopaminergic and glutamatergic excitatory influences on lower urinary tract function in normal and cerebral-infarcted rats

Experimental Neurology
O YokoyamaW C de Groat

Abstract

Previous studies showed that bladder hyperactivity after cerebral infarction in Sprague-Dawley (SD) rats was mediated in part by D2 dopaminergic and NMDA glutamatergic mechanisms. In the present experiments, the interaction between dopaminergic and glutamatergic excitatory mechanisms in the control of bladder and external urethral sphincter (EUS) reflexes was investigated in urethane-anesthetized sham-operated (SO) and cerebral-infarcted (CI) SD rats. Occlusion of the left middle cerebral artery or a sham operation was performed under halothane anesthesia. Two hours after either of the two procedures, rats were anesthetized with urethane. Dizocilpine, an N-methyl-d-aspartate (NMDA) glutamatergic antagonist, was administered intravenously in doses of 0.3 or 3 mg/kg to CI rats and 3 mg/kg to SO rats. These doses completely inhibited bladder and EUS activity. The effects of apomorphine (a dopamine agonist with greater efficacy at D2 than D1 receptors) or quinpirole (a selective D2 dopamine receptor agonist) were examined on the dizocilpine-induced depression of bladder contractions and EUS EMG activity. Apomorphine did not antagonize the dizocilpine depression of EUS activity, but it did reestablish the micturition reflex after di...Continue Reading

References

Apr 19, 1991·Brain Research·B S MalloryW C de Groat
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Jun 1, 1995·The Journal of Urology·B C BennettW C de Groat
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Citations

Feb 14, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hui-Yi ChangWilliam C de Groat
Oct 31, 2012·Computer Methods and Programs in Biomedicine·Antonio Soriano PayaFrancisco Macia Perez
Feb 9, 2006·British Journal of Pharmacology·William C de Groat
Jun 11, 2003·The Journal of Urology·Rikard Pehrson, Karl-Erik Andersson
Apr 7, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Gen YamamotoKazuo Takahama
Jul 19, 2017·The Urologic Clinics of North America·Minoru MiyazatoNaoki Yoshimura
May 26, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rosa De MiccoAlessandro Tessitore

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