Interaction between diltiazem and halothane or enflurane in the canine blood-perfused papillary muscle and sinoatrial node preparations cross-circulated by chronically instrumented conscious donor dog

Journal of Anesthesia
M ManabeK Hashimoto

Abstract

Interaction of cardiovascular effects of diltiazem with those of halothane or enflurane was estimated in the canine isolated papillary muscle and sinoatrial node preparations perfused by arterial blood of the chronically instrumented conscious and halothane- or enflurane-anesthetized donor dog, into which diltiazem was infused i.v. at a rate of 20 micro g/kg/min for 60 min. One hour after diltiazem infusion, in the conscious donor dog, mean arterial pressure (MAP) and heart rate (DHR) were decreased to 84 +/- 3 and 84 +/- 2% and PQ interval (PQ) was prolonged to 148 +/- 5%, while in the isolated preparations, developed tension (DT) of the papillary muscle and sinoatrial rate (SAR) were decreased to 68 +/- 3 and 74 +/- 3% and blood flow (BF) was increased to 155 +/- 5% (n = 10). On the other hand, halothane (0.8%) anesthesia per se decreased MAP, DHR, DT and SAR to 89 +/- 8, 84 +/- 3, 79 +/- 3 and 89 +/- 5% (n = 7) of each basal value in conscious state 20 min after the inhalation. During halothane anesthesia, the same dose of diltiazem infused decreased MAP to 74 +/- 4 (n = 7), DHR to 66 +/- 4 (n = 6), DT to 62 +/- 7 (n = 7) and SAR to 69 +/- 1% (n = 3) of each value suppressed by halothane itself. Meanwhile, enflurane (1.7%) a...Continue Reading

References

May 1, 1970·The American Journal of Physiology·M Endoh, K Hashimoto
May 1, 1983·Journal of Cardiovascular Pharmacology·R K BrowneB Korol
Dec 1, 1980·The American Journal of Cardiology·P D Henry
Nov 1, 1983·Anesthesia and Analgesia·I KissinJ G Reves
Dec 1, 1982·Anesthesiology·J G RevesS Tosone
Apr 1, 1983·Anesthesiology·Z J Bosnjak, J P Kampine
Oct 1, 1981·Anesthesiology·C LynchN Sperelakis

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Citations

Apr 1, 1997·The Australian and New Zealand Journal of Psychiatry·A K Shah, T Ganesvaran
Dec 1, 1992·The Australian and New Zealand Journal of Psychiatry·P Cheung

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