Interaction between exogenous insulin, endogenous insulin, and glucose in type 2 diabetes patients

Diabetes Technology & Therapeutics
Jurgita JanukonytéT Laursen

Abstract

Little is known about the influence of exogenous insulin and actual glucose levels on the release of endogenous insulin in insulin-treated type 2 diabetes mellitus (T2DM) patients. This study investigated the interaction among serum endogenous insulin (s-EI), serum exogenous insulin aspart (s-IAsp), and blood glucose levels in an experimental short-term crossover design. Eight T2DM patients (63.52 years old; range, 49-69 years; mean body mass index, 28.8±3.8 kg/m(2)) were randomized to treatment with individual fixed doses of insulin aspart (0.5-1.5 IU/h) as a continuous subcutaneous insulin infusion (CSII) during a 10-h period on two occasions with different duration of hyperglycemia: (1) transient hyperglycemia for 2 h (visit TH) and (2) continuous hyperglycemia for 12 h (visit CH). During steady state the variances of plasma glucose (p-glucose), s-IAsp, and s-EI were equal within visit TH and within visit CH, but variances were significantly higher during visit CH compared with visit TH. The s-IAsp reached lower levels at visit CH compared with visit TH (test for slope=1, P=0.005). The s-EI depended on p-glucose in a nonlinear fashion during the first 100 min of both visits when s-IAsp was undetectable (adjusted R(2)=0.9). A...Continue Reading

Associated Clinical Trials

References

Apr 28, 2004·Diabetes Care·Edmond A RyanClarissa Wallace
May 15, 2007·Diabetes & Metabolism·B EliassonUNKNOWN Steering Committee of the Swedish National Diabetes Register (NDR)
Jun 27, 2007·Diabetes, Obesity & Metabolism·T ParknerJ S Christiansen
May 1, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·T ParknerJ S Christiansen
Sep 8, 2009·Journal of Pharmaceutical and Biomedical Analysis·Signe Beck PetersenOle Skyggebjerg
Sep 11, 2009·Diabetes, Obesity & Metabolism·R RetnakaranB Zinman
Sep 1, 2007·Journal of Diabetes Science and Technology·Tina ParknerJens S Christiansen
Jun 28, 2011·Diabetes Technology & Therapeutics·David R Owens

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Methods Mentioned

BETA
enzyme-linked immunsorbent assay

Software Mentioned

R

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