PMID: 8958994Nov 18, 1996Paper

Interaction between fibrillin genotype and blood pressure and the development of aneurysmal disease

Annals of the New York Academy of Sciences
J T PowellA M Henney

Abstract

Debate as to whether abdominal aortic aneurysms (AAA) are caused by atherosclerosis or whether they have a strong genetic etiology continues. We have investigated the hypothesis that risk factors are likely to be strongest in patients with generalized aneurysmal disease. We screened 232 consecutive AAA patients for popliteal aneurysm and investigated cardiovascular and genetic risk factors in these patients. Ultrasonography demonstrated the presence of a popliteal aneurysm in 24 of 232 (10%) patients. Multivariate analysis identified four independent factors associated with popliteal aneurysm: age (p = 0.013), height (p = 0.017), triglyceride concentration (p = 0.009), and systolic blood pressure (p = 0.037). In the AAA patients a significant association of fibrillin-1 genotype was present, determined by a tandem repeat polymorphism, with both systolic and pulse pressure. The genotypes associated with the highest pressures were significantly more common among the patients with popliteal aneurysm, p = 0.03. Following these findings we investigated whether there was an association between fibrillin-1 genotype and blood pressure in a healthy population, 245 men aged 50-61 years. Again we found a significant association between fib...Continue Reading

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Citations

May 19, 2012·International Journal of Biological Sciences·Rui-Xing YinMeng Li
Oct 16, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D T BradleyA E Hughes
Jun 19, 2007·The Journal of Surgical Research·Naoe AkimotoYoshito Ikada
Oct 23, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C J van Vlijmen-van KeulenJ A Rauwerda
Sep 24, 2013·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C Y T ChanS W Cheng
Aug 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S T MacSweeneyJ T Powell
Oct 3, 2006·Journal of the American Psychoanalytic Association·Nathan Kravis
Mar 17, 2006·Journal of Applied Physiology· YasminKevin M O'Shaughnessy

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