Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation.

International Journal of Molecular Sciences
Kalaiyarasi RagunathanValentyn Oksenych

Abstract

Cancer-associated fibroblasts (CAF) form the basis of tumor microenvironment and possess immunomodulatory functions by interacting with other cells surrounding tumor, including T lymphocytes, macrophages, dendritic cells and natural killer cells. Ionizing radiation is a broadly-used method in radiotherapy to target tumors. In mammalian cells, ionizing radiation induces various types of DNA damages and DNA damage response. Being unspecific, radiotherapy affects all the cells in tumor microenvironment, including the tumor itself, CAFs and immune cells. CAFs are extremely radio-resistant and do not initiate apoptosis even at high doses of radiation. However, following radiation, CAFs become senescent and produce a distinct combination of immunoregulatory molecules. Radiosensitivity of immune cells varies depending on the cell type due to inefficient DNA repair in, for example, monocytes and granulocytes. In this minireview, we are summarizing recent findings on the interaction between CAF, ionizing radiation and immune cells in the tumor microenvironment.

References

Apr 14, 1999·Cell Death and Differentiation·K NishiiM Greaves
Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·S Kunala, R M Macklis
Oct 12, 2005·Health Physics·Ronald E Goans, Jamie K Waselenko
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Aug 2, 2006·Cell Cycle·Akira Orimo, Robert A Weinberg
Sep 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tom DonnemRoy M Bremnes
Jan 8, 2011·Science·Eric VivierSophie Ugolini
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Martina BauerBernd Kaina
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cristian BoboilaBjoern Schwer
Mar 7, 2012·International Journal of Cancer. Journal International Du Cancer·Karolina EdlundPatrick Micke
Aug 23, 2012·The Journal of Biological Chemistry·Oxana V DenisovaDenis E Kainov
Jan 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Valentyn OksenychFrederick W Alt
Jan 31, 2014·Frontiers in Oncology·Turid Hellevik, Iñigo Martinez-Zubiaurre
May 7, 2014·Biochimica Et Biophysica Acta·Daniel HeylmannBernd Kaina
Nov 2, 2014·Journal of Leukocyte Biology·Wenjuan XuanGuo-Huang Fan
Mar 3, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·A G R MartinN G Burnet
Aug 15, 2015·Trends in Immunology·Carolyn E Rydyznski, Stephen N Waggoner
Nov 8, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea BjörkmanQiang Pan-Hammarström
Dec 3, 2015·Translational Lung Cancer Research·Hiroshi Yokouchi, Kenya Kanazawa
Aug 24, 2016·Nature Reviews. Cancer·Raghu Kalluri
Mar 30, 2017·Frontiers in Immunology·Erik WennerbergSandra Demaria
Sep 21, 2017·Oncology Letters·Leilei TaoLongbang Chen
Jan 25, 2018·Oncogenesis·Varvara PetrovaIvano Amelio

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Citations

Jan 23, 2021·Biomolecules·Valentyn Oksenych, Denis E Kainov

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Methods Mentioned

BETA
X-ray
imaging techniques

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