PMID: 20640385Jul 20, 2010Paper

Interaction between growth differentiation factor 9, insulin-like growth factor I and growth hormone on the in vitro development and survival of goat preantral follicles

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
F S MartinsJ R Figueiredo

Abstract

The objective of this study was to determine the effects of GDF-9, IGF-I, and GH alone or combined on preantral follicle survival, activation and development after 1 and 7 days of in vitro culture. Either fresh (non-cultured) or cultured ovarian tissue was processed for histological and fluorescence analysis. For all media tested, the percent of normal follicles was greater when compared to minimum essential medium supplemented (MEM+) alone, except when ovarian tissue was cultured with GDF-9/IGF-I or GDF-9/GH (P < 0.05). Fluorescence analysis showed that the percent of viable follicles after 7 days of culture was similar for non-cultured tissue and for all treatments tested. The percent of primordial follicles was reduced (P < 0.05) and there was a significant and concomitant increase in the percent of intermediate and primary follicles in all treatments tested after 7 days of culture when compared to non-cultured tissue. After 7 days of culture, the highest percent of intermediate follicles was observed with IGF-I/GH (61.3%), and the highest percent of primary follicles was achieved with IGF-I (57.7%). After 7 days of culture in MEM+ containing GDF-9, IGF-I and GH alone or in all associations, a significant increase in follicu...Continue Reading

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Citations

Apr 6, 2012·Zygote : the Biology of Gametes and Early Embryos·Evelyn R AndradeAmauri A Alfieri
Jan 22, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M K B SerafimJ R Figueiredo
Jan 13, 2015·International Journal of Endocrinology·Kerry L Hull, Steve Harvey
May 14, 2016·General and Comparative Endocrinology·S Marisela Ahumada-SolórzanoCarlos Arámburo
Jun 28, 2016·Reproduction in Domestic Animals = Zuchthygiene·C R JimenezCaa Torres
Oct 28, 2015·Zygote : the Biology of Gametes and Early Embryos·A Y P CavalcanteM H T Matos
Jun 14, 2013·Biology of Reproduction·Deborah M Magalhães-PadilhaEduardo L Gastal
Apr 6, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E V CunhaR P Santos
May 31, 2019·Reproduction in Domestic Animals = Zuchthygiene·Gildas Tetaping MbemyaAna Paula Ribeiro Rodrigues
May 31, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N A R SáJ R Figueiredo
Feb 10, 2021·Animal Reproduction Science·Maiana Silva ChavesMarcos Antônio Lemos Oliveira

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