Interaction between HCMV infection and PAX9 gene polymorphisms in low birth weight infants

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Ning ChengYana Bai

Abstract

To investigate the interaction between human cytomegalovirus infection and PAX9 gene polymorphisms in low birth weight (LBW) infants. Nested-PCR was used to detect human cytomegalovirus (HCMV) infection and restriction fragment length polymorphism PCR (RFLP-PCR) was then used to detect polymorphisms at rs2073244 and rs4904210 on the PAX9 gene in 65 HCMV-positive infant cases and 65 HCMV-negative infant controls. Cases and controls were compared for differences in the rates of LBW using the χ(2) test. Genetic and environmental interactions were assessed by comparing rates of LBW between the cases and controls in stratified analyses and logistic regressions. The study confirmed that HCMV infection is significantly associated with LBW (OR = 5.519, χ(2) = 20.924, p < 0.05) and suggested that some PAX9 polymorphisms may promote the induction of LBW by HCMV infection. The AG and GG genotypes at rs2073244 and the CC genotype at rs4904210, with interaction coefficients greater than unity suggest that they may strengthen the association between HCMV infection and LBW. Congenital HCMV infection can cause LBW and some PAX9 polymorphisms can increase the risk of LBW in HCMV-infected infants. The results may provide new clues into the relat...Continue Reading

References

Aug 1, 1997·Molecular Biology and Evolution·K A BalczarekS Kumar
Sep 23, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E DahlR Balling
Oct 24, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C HofmannC Tickle
Nov 13, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·L Z WenW J Zeng
Dec 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Thomas BeutlerSusanna Prösch
Feb 25, 2003·JAMA : the Journal of the American Medical Association·Karen B FowlerRobert F Pass
Dec 23, 2003·Human Genetics·Dolrudee JumlongrasBjorn R Olsen
Sep 3, 2005·Archives of Oral Biology·Regina C R PeresSérgio R P Line
Apr 29, 2006·Current Opinion in Infectious Diseases·Ira Adams-Chapman, Barbara J Stoll
May 9, 2007·The Pediatric Infectious Disease Journal·Henry C LeeAshima Madan
Feb 5, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Klaus HamprechtRangmar Goelz
May 15, 2009·International Journal of Environmental Research and Public Health·Regina GrazulevicieneJone Vencloviene

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May 10, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Chandra Sekhar BholSujit Kumar Bhutia

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