Interaction between Helicobacter pylori infection and untreated coeliac disease on gastric histological pattern

Scandinavian Journal of Gastroenterology
Luca SantarelliAntonio Gasbarrini

Abstract

Helicobacter pylori infection is the major agent of gastric damage. Coeliac disease may affect the morphology and function of the entire gastrointestinal tract from the stomach to the colon. The aim of this study was to assess the gastric histological pattern in patients with H. pylori and untreated coeliac disease. We retrospectively enrolled 183 H. pylori-positive patients with (85, group A) and without (98, group B) untreated coeliac disease. The groups were similar for age, gender and smoking habit, and all the patients came from the same geographical area. Histological evaluation of gastric pattern was performed on 4 biopsies (2 in the antrum, 2 in the corpus). Gastric damage was classified according to the modified Sydney System. Diagnosis of H. pylori infection was based on positivity to histology. The chi-square test was used to assess differences between groups. A p-value <0.05 was considered significant. Group A showed a significantly higher prevalence of follicular gastritis than group B (23.5% versus 12.2%, p=0.045). A significantly lower prevalence of atrophic gastritis was observed in group A compared with that in group B (6% versus 22.5%, p=0.002). The prevalence of chronic superficial gastritis, activity degree ...Continue Reading

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Citations

Oct 11, 2007·Helicobacter·Ulrich R M BohrAntonio Gasbarrini
Nov 4, 2008·Journal of Pediatric Gastroenterology and Nutrition·Kaushal K PrasadKartar Singh
Aug 22, 2017·Frontiers in Microbiology·Aaron LernerTorsten Matthias

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Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.