PMID: 8964740Mar 1, 1996Paper

Interaction between hypoxia and hypercapnia in regulating canine diaphragm arteriolar diameter

Journal of Applied Physiology
M E Ward

Abstract

In alpha-chloralose-anesthetized mongrel dogs, the microvascular responses to hypoxia and hypercapnia were studied in the vascularly isolated ex vivo left hemidiaphragm. The diaphragm was perfused with arterial blood diverted from the femoral artery by a pump. A series of membrane oxygenators was used to adjust the blood gas composition of the blood perfusing the diaphragm. Arteriolar diameters were measured by intravital microscopy during an infusion of sodium nitroprusside, moderate hypoxia (phrenic venous PO2 25 Torr), severe hypoxia (phrenic venous PO2 13 Torr), hypercapnia (phrenic venous PCO2 100 Torr), and a simultaneous presentation of hypoxia and hypercapnia. Recordings were made after 15 min under each condition when a steady state had been established for vessel diameter and flow. Pump speed was adjusted manually under each condition to ensure that the steady-state perfusion pressure was the same as that under the control condition. Moderate hypoxia generally resulted in dilation; however, vasoconstriction was seen in some arterioles. Severe hypoxia caused vasodilation that was inversely related to baseline vessel diameter and paralleled the response to sodium nitroprusside. Hypercapnia resulted in vasodilation of th...Continue Reading

Citations

Jan 23, 2003·Anesthesia and Analgesia·Zoë L S BrookesCharles S Reilly
Oct 1, 1996·Journal of Applied Physiology·S N Hussain
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·M Toporsian, M E Ward
Dec 4, 2003·Medicine and Science in Sports and Exercise·Ine De ClerckJohan Van De Voorde
Jun 5, 2004·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Satomi ShiotaYoshinosuke Fukuchi

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