Interaction between IgE complexes and macrophages in the rat: a new mechanism of macrophage activation

European Journal of Immunology
A CapronH Bazin

Abstract

In earlier studies we found that normal rat macrophages, preincubated at 37 degrees C with the serum of syngeneic rats immune to Schistosoma mansoni, strongly adhered to S. mansoni schistosomules whereas no significant adherence was induced with serum from normal rat. Using 51 chromium release assay, it now proved that immune serum-incubated macrophages lysed the schistosomules in 18 h. Absorption experiments and ultracentrifugation of the immune serum showed that immune complexes containing specific IgE antibody against S. mansoni and soluble parasite antigens induced macrophage adherence and cytotoxicity. Using various labeling techniques, the binding of aggregated rat IgE to the macrophage surface at 37 degrees C is evident in conditions where endocytosis is neglible. The binding of immune complexes containing IgE antibody to S. mansoni elicits dramatic ultrastructural changes in the macrophage and an increase of its lysosomal enzymes together with specific lytic activity for the schistosomules. The parallel development of immune serum-induced macrophage adherence or cytotoxicity with the level of circulating IgE antibody to the parasite in correlation with the development of immunity in the rat, suggests that this new mecha...Continue Reading

References

Jan 1, 1976·Advances in Parasitology·S R Smithers, R J Terry
Dec 31, 1971·Annals of the New York Academy of Sciences·K Ishizaka, T Ishizaka
May 1, 1974·The American Journal of Tropical Medicine and Hygiene·D A DeanK D Murrell
Jan 1, 1966·The Journal of Experimental Medicine·A Berken, B Benacerraf
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Dec 6, 1974·Nature·A E ButterworthP H Rees
Mar 1, 1972·International Journal for Parasitology·J A Clegg, S R Smithers
Jul 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·T F DOUGHERTY, R D HIGGINBOTHAM

Citations

Jan 1, 1986·Archives of Dermatological Research·C Bruynzeel-KoomenP L Bruynzeel
Dec 1, 1980·Acta Tropica. Supplementum·L Haller
Mar 1, 1985·Agents and Actions·M Joseph, A Capron
May 7, 1982·European Journal of Pharmacology·A PrancanB B Vargaftig
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·R F SturrockV Houba
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·A CapronM Joseph
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·A E ButterworthR F Sturrock
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·A A GbakimaB M Greene
Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·E Schneider, M Dy
Nov 1, 1982·Molecular Immunology·R Rousseaux-PrevostH Bazin
Nov 1, 1979·Veterinary Immunology and Immunopathology·J Rousseaux, H Bazin
Jan 1, 1981·International Journal of Immunopharmacology·M JosephA Capron
Jan 1, 1988·International Journal of Immunopharmacology·T ThorelM Pascal
Jun 1, 1982·Veterinary Parasitology·R W Leid
Jan 1, 1981·Annales d'immunologie·A Capron, J P Dessaint
Mar 1, 1990·Research in Immunology·H Kikutani, T Kishimoto
Feb 17, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·Z ZhangG Wu
Nov 21, 1998·Veterinary Parasitology·A PazP Morrondo
Oct 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S O FormanM H Grieco
Aug 1, 1981·The Journal of Experimental Medicine·G Boltz-NitulescuH L Spiegelberg
Jun 1, 1996·The Journal of Experimental Medicine·J MonteseirínF Sobrino
Jan 1, 1993·Parasite Immunology·P Hagan
Jan 1, 1979·Scandinavian Journal of Immunology·U Hellström, H L Spiegelberg
Jan 1, 1992·British Journal of Pharmacology·S Fernández-GallardoM Sánchez Crespo
Feb 1, 1983·The Journal of Clinical Investigation·M JosephJ Benveniste
May 1, 1986·Annales De L'Institut Pasteur. Immunology·H L SpiegelbergN R Ferreri
May 1, 1986·Annales De L'Institut Pasteur. Immunology·J A Rankin
Jun 1, 1983·Scandinavian Journal of Dental Research·A C JohannessenN Skaug
Mar 1, 1993·International Endodontic Journal·I J Marton, C Kiss
Mar 1, 1997·Revista Da Sociedade Brasileira De Medicina Tropical·M I Muniz-JunqueiraC E Tosta
Mar 1, 1980·Clinical Immunology and Immunopathology·H L Spiegelberg, F M Melewicz
Sep 1, 1981·Immunology Today·E E Jarrett
Jan 1, 1980·International Journal of Nuclear Medicine and Biology·J P DessaintA Capron
Dec 1, 1977·Cellular Immunology·M JosephA Capron
Mar 15, 1981·Cellular Immunology·G Boltz-Nitulescu, H L Spiegelberg
Jun 1, 1992·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·B Langkamp-HenkenK A Kudsk
Jul 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L Escoubet-LozachB Pipy
May 27, 1982·Nature·J A RankinP W Askenase
Jan 1, 1982·Immunological Reviews·A CapronG Torpier
Jan 1, 1982·Immunological Reviews·A E ButterworthE Wells
Aug 1, 1992·Immunological Investigations·A J DesseinA Bourgois
Nov 1, 1995·The British Journal of Dermatology·C BuckleyL W Poulter
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D DombrowiczM Capron

Related Concepts

Antigen-Antibody Reactions
Antigens
Microcytotoxicity Test
Immunoglobulin E
Immune Sera
Cellular Immune Response
Lymphocyte Activation
Macrophage
August Rats
Schistosoma mansoni

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.