Jul 18, 1989

Interaction between isoproterenol and dihydropyridines in heart cells

European Journal of Pharmacology
V BriandH Schmitt

Abstract

The negative inotropic potencies (IC50) of the calcium channel blockers nicardipine (12 +/- 2 nM) and nifedipine (9 +/- 2 nM) measured in cultured chick embryo ventricular cells were not significantly different. Exposure of the cells to isoproterenol potentiated the negative inotropic effect of low concentrations of nicardipine (10(-9)-10(-8) M) and decreased the effect of higher concentrations (10(-7) M). In contrast, isoproterenol shifted the entire dose-response curve for nifedipine to the right. These results provide evidence that activation of beta-adrenoceptors modulates the negative inotropic effect of nifedipine and nicardipine differently.

Mentioned in this Paper

Myocardial Contraction
Nifedipine
Bay-K-8644, (-)-Isomer
Myocardium
Dihydropyridines
Adrenergic Receptor
Fenigidin
Novodrin
Chick Embryo
Heart

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.